Genetic polymorphisms of the IGF-II gene intron 8 coding region and its association with growth and carcass traits in yak

文献类型： 外文期刊

第一作者： Zeng, Y. F.

作者： Zeng, Y. F.;Yu, S. J.;Zeng, Y. F.;Ding, X. Z.;Cheng, S. R.

作者机构：

关键词： Yak;Insulin-like growth factor II;Polymorphism;Growth traits

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2013 年 12 卷 4 期

页码：

收录情况： SCI

摘要： Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth and is involved in stimulating fetal cell division, differentiation, and metabolic regulation. IGF-II is considered a candidate gene for genetic markers of growth and carcass traits. Therefore, in this study, the associations of single nucleotide polymorphisms (SNPs) in the IGF-II gene region with growth and carcass characteristics in five yak breeds were investigated. Two SNPs, G(330)C and A(358)G, were identified by sequencing intron 8 of the IGF-II gene in homozygotes. Two alleles, A and B, and three genotypes, AA, AB, and BB, were identified by polymerase chain reaction. Genotypic frequencies of IGF-II allele B were 0.8623, 0.8936, 0.8535, 0.8676, and 0.8300 for Datong yak, Gannan yak, Tianzhu white yak, Qinghai Plateau yak, and Xinjiang yak, respectively. Allele and the genotype of IGF-II were strongly associated with growth and carcass traits. Least square analysis revealed a significant effect (P < 0.01) of genotypes AA and AB compared with genotype BB on live-weight (at 12, 13-24, and 25-36 months of age), average daily weight gain (P < 0.01) and carcass weight (P < 0.05). Animals with genotype AB had a higher mean rib eye area, and a lower mean yield grade. The results indicated that the IGF-II gene acts by a primarily additive biological mechanism by adding weight independently of skeletal growth.

分类号：

  • 相关文献

[1]Genotypes, haplotypes and diplotypes of IGF-II SNPs and their association with growth traits in largemouth bass (Micropterus salmoides). Li, Xiaohui,Bai, Junjie,Hu, Yinchang,Ye, Xing,Li, Shengjie,Yu, Lingyun,Li, Xiaohui.

[2]Genetic variation in the kappa-casein gene (CSN3) of Chinese yak (Bos grunniens) and phylogenetic analysis of CSN3 sequences in the genus Bos. Prinzenberg, E. -M.,Erhardt, G.,Jianlin, H.,Jianlin, H.. 2008

[3]Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak (Bos grunniens). Wu Xiao-yun,Ding Xue-zhi,Chu Min,Guo Xian,Bao Peng-jia,Liang Chun-nian,Yan Ping. 2015

[4]Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens). Chu, M.,Wu, X. Y.,Guo, X.,Pei, J.,Liang, C. N.,Ding, X. Z.,Bao, P. J.,Yan, P.,Chu, M.,Wu, X. Y.,Guo, X.,Pei, J.,Liang, C. N.,Ding, X. Z.,Bao, P. J.,Yan, P.,Jiao, F.,Fang, H. T.. 2015

[5]Conserved Exon 2 but a Highly Polymorphic 5 '-UTR of Tyrosinase Gene in Tianzhu White Yak (Bos grunniens). Zhang, H.,Han, J. L.,Zhang, H.,Luo, Y. Z.,An, T. W.,He, J. W.,Han, J. L.. 2012

[6]A novel single nucleotide polymorphism in exon 7 of LPL gene and its association with carcass traits and visceral fat deposition in yak (Bos grunniens) steers. Ding, X. Z.,Liang, C. N.,Guo, X.,Xing, C. F.,Bao, P. J.,Chu, M.,Pei, J.,Zhu, X. S.,Yan, P.. 2012

[7]Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens). Wu, X. Y.,Liang, C. N.,Ding, X. Z.,Guo, X.,Bao, P. J.,Chu, M.,Liu, W. B.,Yan, P.,Wu, X. Y.,Liang, C. N.,Ding, X. Z.,Guo, X.,Bao, P. J.,Chu, M.,Liu, W. B.,Yan, P.. 2013

[8]Comparison of genetic diversity and growth traits among Fangzheng silver crucian carp (Carassius auratus gibelio) gynogenetic clones. Lu, C. Y.,Cheng, L.,Li, C.,Zheng, X. H.,Cao, D. C.,Sun, X. W.. 2016

[9]Effects of high pressure treatment and temperature on lipid oxidation and fatty acid composition of yak (Poephagus grunniens) body fat. Wang, Qiang,Zhao, Xin,Ren, Yanrong,Wang, Qiang,Chang, Haijun,Wu, Hongbin,Fan, Enguo. 2013

[10]The Breed and Sex Effect on the Carcass Size Performance and Meat Quality of Yak in Different Muscles. Zhang, Li,Yu, Qunli,Wang, Li,Zhou, Yuchun,Li, Yongpeng,Sun, Baozhong,Xie, Peng,Li, Haipeng,Huang, Caixia,Liu, Xuan,Ji, Qiumei. 2016

[11]Effect of urea multinutritional molasses block supplementation on liveweight change of yak calves and productive and reproductive performances of yak cows. Dong, SK,Long, RJ,Kang, MY,Pu, XP,Guo, YJ. 2003

[12]Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. Zhang, Xiao-Xuan,Ma, Jian-Gang,Zheng, Wen-Bin,Zhao, Quan,Zhang, Xiao-Xuan,Feng, Sheng-Yong,Ma, Jian-Gang,Zheng, Wen-Bin,Yin, Ming-Yang,Qin, Si-Yuan,Zhou, Dong-Hui,Zhu, Xing-Quan. 2017

[13]Foot-and-mouth disease virus carrier status in Bos grunniens yaks. Chang, Huiyun,Ma, Yanbin,Lin, Tong,Cong, Guozheng,Du, Junzheng,Ma, Jinling. 2013

[14]Molecular and serological evidence for Anaplasma infection in yaks. Ma, Miling,Liu, Zhijie,Guan, Guiquan,Li, Youquan,Luo, Jianxun,Yin, Hong.

[15]Comparative Proteomic Analysis of Yak Follicular Fluid during Estrus. Guo, Xian,Pei, Jie,Ding, Xuezhi,Chu, Min,Bao, Pengjia,Wu, Xiaoyun,Liang, Chunnian,Yan, Ping.

[16]PPAR alpha signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle. Qin, W.,Liang, C. N.,Guo, X.,Chu, M.,Pei, J.,Bao, P. J.,Wu, X. Y.,Li, T. K.,Yan, P.. 2015

[17]Molecular investigation of bovine viral diarrhea virus infection in yaks (Bos gruniens) from Qinghai, China. Gong, Xiaowei,Zheng, Fuying,Chen, Qiwei,Li, Zhaocai,Cao, Xiaoan,Yin, Hong,Zhou, Jizhang,Cai, Xuepeng. 2014

[18]Efficiency of in vitro embryo production of yak (Bos grunniens) cultured in different maturation and culture conditions. Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping,Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping. 2012

[19]Comparative proteomics of milk fat globule membrane in different species reveals variations in lactation and nutrition. Lu, Jing,Zhang, Weiqing,Liu, Lu,Pang, Xiaoyang,Zhang, Shuwen,Lv, Jiaping,Wang, Xinyu,Wang, Xinyu.

[20]Expression profiles of growth hormone receptor and insulin-like growth factor I in cattle and yak tissues revealed by quantitative real-time PCR. Pei, Jie,Lang, Xia,Guo, Xian,Bao, Pengjia,Liang, Chunnian,Chu, Min,Feng, Ruilin,Yan, Ping,Pei, Jie,Lang, Xia,Guo, Xian,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping. 2013

作者其他论文 更多>>

微信小程序