Stably transmitted defined microbial community in honeybees preserves Hafnia alvei inhibition by regulating the immune system

文献类型： 外文期刊

第一作者： Wang, Jieni

作者： Wang, Jieni;Lang, Haoyu;Zheng, Hao;Zhang, Wenhao;Zhai, Yifan;Zheng, Li;Chen, Hao;Liu, Yan;Zhai, Yifan;Zheng, Li;Chen, Hao;Liu, Yan

作者机构：

关键词： Apis mellifera; colonization resistance; Hafnia alvei; immune system; gut microbiota

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）

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年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： The gut microbiota of honeybees is highly diverse at the strain level and essential to the proper function and development of the host. Interactions between the host and its gut microbiota, such as specific microbes regulating the innate immune system, protect the host against pathogen infections. However, little is known about the capacity of these strains deposited in one colony to inhibit pathogens. In this study, we assembled a defined microbial community based on phylogeny analysis, the 'Core-20' community, consisting of 20 strains isolated from the honeybee intestine. The Core-20 community could trigger the upregulation of immune gene expressions and reduce Hafnia alvei prevalence, indicating immune priming underlies the microbial protective effect. Functions related to carbohydrate utilization and the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS systems) are represented in genomic analysis of the defined community, which might be involved in manipulating immune responses. Additionally, we found that the defined Core-20 community is able to colonize the honeybee gut stably through passages. In conclusion, our findings highlight that the synthetic gut microbiota could offer protection by regulating the host immune system, suggesting that the strain collection can yield insights into host-microbiota interactions and provide solutions to protect honeybees from pathogen infections.

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