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Synthesis and Fungicidal Activity of Novel N-Nitro-2-pyrimidinamine Derivatives

文献类型：外文期刊

第一作者： Zhao, Jian

作者： Zhao, Jian;Gao, Beibei;Chen, Shuo;Jiang, Zhifu;Ning, Jun;Yuan, Huizhu;She, Dongmei

作者机构：

关键词： N-nitro-2-pyrimidinamine;fungicidal activity;synthesis;structure-activity

期刊名称：ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5

ISSN： 1022-6680

年卷期： 2013 年 634-638 卷

页码：

收录情况： SCI

摘要： Two series of novel N-nitro-2-pyrimidinamine derivatives were synthesized from ethyl acetoacetate, dimethyl malonate and nitroguanidine with good yields and high efficiency. The fungicidal activities of the synthesized compounds against nine fungal species were studied both in vitro and in vivo. Some of these compounds like 4,6-dihydr oxy -N-nitro-2-pyrimidinamine and 4,6-dihydroxy-5-isopentyl-N-nitro-2-pyrimidinamine showed obvious inhibitory of the mycelium growth at 50 mg/L. The structure-activity relationship of these compounds was also discussed.

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