文献类型： 外文期刊
第一作者： Yang, Guang-Li
作者： Yang, Guang-Li;Fu, Dong-Li;Wang, Yu-Tao;Cheng, Shu-Ru;Fang, Su-Li;Luo, Yu-Zhu;Lang, Xia
作者机构：
期刊名称：SCIENTIFIC WORLD JOURNAL （ 影响因子：1.219； 五年影响因子：1.3 ）
ISSN： 1537-744X
年卷期： 2013 年
页码：
收录情况： SCI
摘要： The melanocortin receptor 1 (MC1R) plays a central role in regulation of animal coat color formation. In this study, we sequenced the complete coding region and parts of the 5'- and 3'-untranslated regions of the MC1R gene in Chinese sheep with completely white (Large-tailed Han sheep), black (Minxian Black-fur sheep), and brown coat colors (Kazakh Fat-Rumped sheep). The results showed five single nucleotide polymorphisms (SNPs): two non-synonymous mutations previously associated with coat color (c.218 T>A, p.73 Met>Lys.c.361 G>A, p.121 Asp>Asn) and three synonymous mutations (c.429 C>T, p. 143 Tyr>Tyr; c.600 T>G, p. 200 Leu>Leu. c.735 C>T, p. 245 Ile>Ile). Meanwhile, all mutations were detected in Minxian Black-fur sheep. However, the two nonsynonymous mutation sites were not in all studied breeds (Large-tailedHan, Small-tailed Han, Gansu Alpine Merino, and China Merino breeds), all of which are in white coat. A single haplotype AATGT (haplotype3) was uniquely associated with black coat color in Minxian Black-fur breed (P = 9.72E - 72, chi-square test). The first and second A alleles in this haplotype 3 represent location at 218 and 361 positions, respectively. Our results suggest that the mutations of MC1R gene are associated with black coat color phenotype in Chinese sheep.
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