Sequential drug release for synergistic cancer treatment and immunity promotion

文献类型： 外文期刊

第一作者： Chen, Mingsheng

作者： Chen, Mingsheng;Zhu, Xinyuan;Yan, Deyue;Chen, Mingsheng

作者机构：

期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）

ISSN： 2046-2069

年卷期： 2013 年 3 卷 32 期

页码：

收录情况： SCI

摘要： Rehabilitation of patients is closely related to immunity improvement, while almost all anticancer drugs kill leukocytes, one kind of important immune cell, to silence the immune system. Therefore, it is particularly important to protect leukocytes in the process of cancer chemotherapy. In this work, a sequential drug release for synergistic cancer treatment and immunity promotion has been constructed. Firstly, hyperbranched glycidol (HPG) was synthesized by cationic ring-opening polymerization. Benefiting from the existence of many hydroxyl end-groups in HPG, the traditional Chinese medicine norcantharidin (NCTD) anhydride could be readily conjugated onto the polyols via ester linkages, forming HPG-NCTD conjugates. Owing to the coordination between cisplatin (CDDP) and the carboxyl groups in the HPG-NCTD conjugates, the nanoscale HPG-NCTD/CDDP complexes were obtained. Both in vitro and in vivo evaluations showed that the sequential release of CDDP and NCTD was achieved by the combination of coordination connections and hydrolysable ester bonds. Correspondingly, a synergistic efficiency of cancer treatment and immunity promotion was realized. These experimental results confirm that the sequential release of carriers based on coordination connections and degradable covalent bonds can be used to overcome the problems of leukopenia in cancer therapy, giving us a greater perspective in cancer treatment.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Biased mutations and gene losses underlying diploidization of the tetraploid broomcorn millet genome

    作者：Sun, Yanling;Liu, Yang;Shi, Jinfeng;Liang, Chengzhi;Chen, Mingsheng;Sun, Yanling;Liu, Yang;Liang, Chengzhi;Chen, Jinfeng;Chen, Mingsheng;Liu, Yang;Chen, Jinfeng;Wang, Lun;Yang, Jun;Yang, Jun

    关键词：broomcorn millet; polyploid; diploidization; gene loss; transposable element

  • A route to de novo domestication of wild allotetraploid rice

    作者：Yu, Hong;Lin, Tao;Meng, Xiangbing;Du, Huilong;Zhang, Jingkun;Liu, Guifu;Chen, Mingjiang;Jing, Yanhui;Kou, Liquan;Li, Xiuxiu;Gao, Qiang;Liang, Yan;Cheng, Zhukuan;Chen, Mingsheng;Wang, Yonghong;Chu, Chengcai;Zuo, Jianru;Liang, Chengzhi;Li, Jiayang;Yu, Hong;Lin, Tao;Meng, Xiangbing;Du, Huilong;Zhang, Jingkun;Liu, Guifu;Chen, Mingjiang;Jing, Yanhui;Kou, Liquan;Li, Xiuxiu;Gao, Qiang;Liang, Yan;Cheng, Zhukuan;Chen, Mingsheng;Wang, Yonghong;Chu, Chengcai;Zuo, Jianru;Liang, Chengzhi;Li, Jiayang;Du, Huilong;Zhang, Jingkun;Li, Xiuxiu;Cheng, Zhukuan;Chen, Mingsheng;Tian, Zhixi;Wang, Yonghong;Chu, Chengcai;Zuo, Jianru;Gao, Caixia;Liang, Chengzhi;Li, Jiayang;Liu, Xiangdong;Li, Jiayang;Liu, Xiangdong;Fan, Zhilan;Liang, Yuntao;Tian, Zhixi;Gao, Caixia;Wan, Jianmin;Qian, Qian;Han, Bin;Han, Bin;Zuccolo, Andrea;Wing, Rod A.;Zuccolo, Andrea;Wing, Rod A.;Lin, Tao

    关键词：

  • Parallel selection on a dormancy gene during domestication of crops from multiple families

    作者：Wang, Min;Fang, Chao;Liu, Yucheng;Wang, Zheng;Yang, Rui;Zhang, Min;Liu, Shulin;Zhu, Baoge;Tian, Zhixi;Wang, Min;Li, Wenzhen;Fang, Chao;Xu, Fan;Liu, Yucheng;Liu, Shulin;Chen, Mingsheng;Chu, Chengcai;Tian, Zhixi;Li, Wenzhen;Xu, Fan;Lin, Tao;Tang, Jiuyou;Wang, Yiqin;Wang, Hongru;Chen, Mingsheng;Chu, Chengcai;Lu, Sijia;Kong, Fanjiang;Liu, Baohui;Lu, Sijia;Kong, Fanjiang;Liu, Baohui;Lin, Hao;Zeng, Dali;Jackson, Scott A.

    关键词：

  • WHITE PANICLE3, a Novel Nucleus-Encoded Mitochondrial Protein, Is Essential for Proper Development and Maintenance of Chloroplasts and Mitochondria in Rice

    作者：Li, Hongchang;Ji, Guobiao;Wang, Yun;Xu, Jichen;Zhao, Xianfeng;Chen, Mingsheng;Zhai, Wenxue;Li, Dayong;Zhu, Lihuang;Li, Hongchang;Ji, Guobiao;Wang, Yun;Xu, Jichen;Zhao, Xianfeng;Chen, Mingsheng;Zhai, Wenxue;Li, Dayong;Zhu, Lihuang;Li, Hongchang;Qian, Qian;Sodmergen;Liu, Guozhen

    关键词：WHITE PANICLE3 (WP3); white stripe; white panicle; mitochondria; chloroplast; rice

  • Population genetics of foxtail millet and its wild ancestor

    作者：Chen, Jinfeng;Yang, Lu;Chen, Mingsheng;Wang, Chunfang;Zhi, Hui;Diao, Xianmin;Wang, Chunfang;Zhi, Hui;Li, Wei;Wang, Yongfang;Li, Haiquan;Diao, Xianmin;Wang, Chunfang;Zhao, Baohua

    关键词：

  • QTLs and candidate genes for chlorate resistance in rice (Oryzasativa L.)

    作者：Teng, Sheng;Tian, Chaoguang;Chen, Mingsheng;Zeng, Dali;Guo, Longbiao;Zhu, Lihuang;Han, Bin;Qian, Qian

    关键词：rice;chlorate resistance;QTL analysis;nitrate reductase;nitrate transporter

  • Hyperbranched glycoconjugated polymer from natural small molecule kanamycin as a safe and efficient gene vector

    作者：Chen, Mingsheng;Zhou, Linzhu;Tu, Chunlai;Zhu, Qi;Zhu, Xinyuan;Yan, Deyue;Wu, Jieli;Jin, Chengyu;Zhu, Bangshang;Zhu, Xinyuan;Chen, Mingsheng;Wu, Fuan;Chen, Mingsheng;Wu, Fuan

    关键词：

微信小程序