Staphylococcus aureus infection of intestinal epithelial cells induces human umbilical cord-derived mesenchymal stem cell migration

文献类型： 外文期刊

第一作者： Li, Yang

作者： Li, Yang;Liu, Ming-yuan;Wang, Xue-lin;Han, Wen-yu;Liu, Ya-hui;Suo, Jian;Li, Zhi-jie;Li, Ya-gang;Jin, Hu

作者机构：

关键词： Staphylococcus aureus;Mesenchymal stem cells;Inflammation;siRNA;NF-kappa B signaling pathway

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2013 年 15 卷 1 期

页码：

收录情况： SCI

摘要： There is a growing interest in umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) for cellular therapy in regenerative medicine. To aid in tissue repair, MSCs are recruited to sites of inflammation induced by a bacterial infection. The primary objective of this study was to explore the mechanisms of MSC recruitment to intestinal epithelial cells infected with Staphylococcus aureus. First, we isolated and characterized the UCB-derived MSCs used in our experiments. Next, we determined the ability of S. aureus infected intestinal epithelial cells to induce migration of UCB-derived MSCs. Expression analysis of cytokines secreted by infected epithelial cells indicated that MSC migration occurred predominately via a nuclear factor-kappa B (NF-kappa B)-dependent signaling pathway. Altogether, our data provide the first evidence for a role of S. aureus infection in MSC migration and reveal the function of UCB-derived MSCs in intestinal pathophysiology. (C) 2012 Elsevier B.V. All rights reserved.

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