Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration

文献类型： 外文期刊

第一作者： Li, Guanghui

作者： Li, Guanghui;Yang, Fan;He, Limin;Ding, Huanzhong;Sun, Na;Liu, Yingchun;Liu, Yiming;Shan, Qi;Li, Yafei;Zeng, Zhenling;Li, Guanghui;Yang, Fan;Liu, Yingchun;Liu, Yiming

作者机构：

关键词： Mequindox;Metabolites;Pharmacokinetics;Rat

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

ISSN： 0034-5288

年卷期： 2012 年 93 卷 3 期

页码：

收录情况： SCI

摘要： Pharmacokinetics of mequindox (MEQ) and its metabolites were determined in rats after intravenous (i.v.) and oral (p.o.) administration of MEQ at a single dose of 10 mg kg(-1) bodyweight. After both administrations, MEQ and five of its metabolites were quantified, except M4, whereas M1 and M2 were the predominant ones. The areas under the concentration-time curves (h ng mL(-1)) of MEQ M1, M2, M3, M5 and M10 after i.v. administration were 7559 +/- 495, 6354 +/- 2761, 5586 +/- 2337, 1034 +/- 160, 2370 +/- 791 and 1813 +/- 622, respectively, whereas after p.o. administration, remained as 2809 +/- 40, 4361 +/- 3544, 4351 +/- 1046, 1444 +/- 814, 3864 +/- 305 and 1213 +/- 569, respectively. The elimination half-lives (h) of these compounds after i.v. administration were 3.48 +/- 0.80, 4.20 +/- 0.76, 6.25 +/- 2.41, 4.77 +/- 1.54, 4.69 +/- 1.62 and 16.89 +/- 5.15, respectively, and were 3.21 +/- 0.40, 3.66 +/- 1.06, 4.20 +/- 1.03, 8.91 +/- 5.99, 4.20 +/- 2.02 and 20.84 +/- 10.85 after p.o. administration, respectively. After p.o. administration, the bioavailability of MEQ was 37.16%. The results showed that MEQ was extensively metabolized in rats and rapidly absorbed after p.o. administration. (C) 2012 Elsevier Ltd. All rights reserved.

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