Flaxseed oil and alpha-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet

文献类型： 外文期刊

第一作者： Xu, Jiqu

作者： Xu, Jiqu;Deng, Qianchun;Huang, Qingde;Yang, Jin'e;Huang, Fenghong;Xu, Jiqu;Deng, Qianchun;Huang, Qingde;Yang, Jin'e;Huang, Fenghong;Yang, Wei

作者机构：

关键词： Flaxseed oil;alpha-lipoic acid;Atherosclerosis;Oxidant stress;Plasma lipids;Inflammation

期刊名称：LIPIDS IN HEALTH AND DISEASE （ 影响因子：3.876； 五年影响因子：4.047 ）

ISSN： 1476-511X

年卷期： 2012 年 11 卷

页码：

收录情况： SCI

摘要： Background: Atherosclerosis is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and a-lipoic acid (LA) have been reported to exert potential benefit to cardiovascular system. This study tried to assess the effect of supplement of FO and LA combination on the atherosclerosis risk factors in rats fed a high-fat diet. Methods: LA was dissolved in flaxseed oil to a final concentration of 8 g/kg (FO+LA) when used. The rodent diet contained 20% fat. One-fifth of the fat was soybean oil and the others were lard (HFD group), or 75% lard and 25% FO+LA (L-FO+LA group), or 50% lard and 50% FO+LA (M-FO+LA group), or FO+LA (H-FO+LA group). Animals were fed for 10 weeks and then killed for blood collection. Results: Supplement of FO and LA combination significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the activities of SOD, CAT and GPx as well as the level of GSH, and the significant reduction in lipid peroxidation. Simultaneous intake of FO and LA also reduced plasma TG, TC and LDL-C contents and elevated the ratio of HDL-C/LDL-C. Besides, in parallel with the increase of FO and LA combination, plasma IL-6 and CRP levels were remarkably reduced. Conclusion: Supplement of FO and LA combination may contribute to prevent atherogenesis by improving plasma oxidative stress, lipid profile and inflammation.

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