Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats

文献类型： 外文期刊

第一作者： Zhu, Yanzhu

作者： Zhu, Yanzhu;Li, Yanfei;Zhu, Yanzhu;Miao, Liguang;Li, Xinwei;Chen, Chongxiao;Wang, Fan;Li, Jing;Hu, Chongwei

作者机构：

关键词： Aluminum;Spleen;Trace elements;Cytokines;Rats

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2012 年 50 卷 8 期

页码：

收录情况： SCI

摘要： The bioaccumulation and immunotoxicity of aluminum (Al) have been previously documented. Al accumulates in the organs of the organism, including spleen. Spleen is a peripheral organ of the immune system. The accumulated Al may alter the immune function. Here, we investigated the bioaccumulation of Al in spleen and its alterations in the immune system. Forty male Wistar rats (5 weeks old) weighed 110-120 g were orally exposed to aluminum trichloride (AlCl3) (0, 64.18, 128.36 and 256.72 mg/kg body weight) in drinking water for 120 days. The concentrations of spleen's Al, iron (Fe), copper (Cu), zinc (Zn), interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-alpha) and growth index were examined at the end of the experiment. The results showed that the concentrations of Al and Cu in the spleen were increased in an AlCl3-dose dependent manner, and the concentrations of spleen's growth index, Fe, Zn, IL-2 and TNF-alpha were reduced in AlCl3-treated rats. The results suggest that AlCl3 can suppress the growth of spleen, disorder the balance of trace elements and inhibit the immune regulation of cytokines in the spleen. It indicates that AlCl3 suppresses the immune function of spleen. (C) 2012 Elsevier Ltd. All rights reserved.

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