Phloretin induced apoptosis of human hepatoma cells SMMC-7721 and its correlative biological mechanisms
文献类型: 外文期刊
第一作者: Wang, Hui
作者: Wang, Hui;Pu, Yabin;Guan, Weijun;Ma, Yuehui;Wang, Hui;Wang, Dianjun;Pan, Dengkui
作者机构:
关键词: Apoptosis;phloretin;human hepatoma cells;SMMC-7721 cells
期刊名称:AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY ( 影响因子:0.839; 五年影响因子:0.875 )
ISSN: 1996-0816
年卷期: 2012 年 6 卷 9 期
页码:
收录情况: SCI
摘要: In order to investigate the proliferative and apoptotic effects of phloretin on human hepatoma cell line SMMC-7721 and to explore the mechanisms of phloretin induced apoptosis, this research is set to observed morphological alterations with phase contrast and confocal microscopy, performed MTT assay, and detected apoptotic rates, cell cycle progression, mitochondrial trans-membrane potential and intracellular calcium homeostasis. The results suggested that typical apoptotic morphological alterations occurred after phloretin treatment. Phloretin exerts a strong inhibitory on the proliferation of SMMC-7721 cell line, and induces its apoptosis in a dosage and duration dependent manner. Cell cycle was arrested at G1 phase. Mitochondrial trans-membrane potential dropped. Calcium homeostasis was disturbed. It is concluded that phloretin can induce apoptosis of SMMC-7721 via arresting cell cycle progression, reducing mitochondrial trans-membrane potential and disturbing intracellular calcium homeostasis.
分类号:
- 相关文献
作者其他论文 更多>>
-
Controllable self-cleaning FET self-assembled RNA-cleaving DNAzyme based DNA nanotree for culture-free Staphylococcus aureus detection
作者:Wang, Hui;Chen, Ruipeng;He, Yue;Zhu, Xiaoyan;Yu, Zhixue;Pan, Dongxia;Yang, Liang;Tang, Xiangfang;Xiong, Benhai;Feng, Zemeng;He, Yue
关键词:Self-cleaning field effect transistor; DNA origami; Electrochemical biosensor; Carbon nanotube; Superhydrophobic-oleophobic coating
-
Humoral and cellular immune responses following Omicron BA.2.2 breakthrough infection and Omicron BA.5 reinfection
作者:Zhao, Xin-Jing;Fang, Li-Qun;Zhao, Xin-Jing;Li, De-Yu;Zhang, Sheng;Gu, Hong-Jing;Chen, Jin-Jin;Xu, Qiang;Lv, Chen-Long;Jiang, Bao-Gui;Wang, Hui;Wang, Guo-Lin;Fang, Li-Qun;Ji, Bin;Peng, Hong-Hong;Shi, Chao;Shen, Yuan;Shang, Chao;Zhang, Cui-Ling;Li, Xiao;Qian, Cheng
关键词:
-
Unraveling the regulatory network of miRNA expression in Potato Y virus-infected of Nicotiana benthamiana using integrated small RNA and transcriptome sequencing
作者:Song, Hongping;Zhang, Songbai;Gao, Xinwen;Song, Liyun;Jiao, Yubing;Shen, Lili;Yang, Jinguang;Li, Ying;Li, Changquan;Shang, Jun;Wang, Hui
关键词:high-throughput sequencing; miRNA; Potato virus Y; miRNA-mRNA network; viral infection
-
Porphyrin-based covalent organic framework as oxidase mimic for highly sensitive colorimetric detection of pesticides
作者:Liu, Qingju;Zhu, Junyi;Wang, Hui;Luan, Yunxia;Zhang, Zhikun
关键词:Porphyrin-based covalent organic framework; Oxidase mimics; Colorimetric detection; Pesticides
-
Protein Lactylation Profiles Provide Insights into Molecular Mechanisms Underlying Metabolism in Yak
作者:Wu, Zhijuan;Chai, Zhixin;Cai, Xin;Wang, Jiabo;Wang, Hui;Yue, Binglin;Zhang, Ming;Wang, Jikun;Wang, Haibo;Zhong, Jincheng;Zhong, Jincheng;Xin, Jinwei;Xin, Jinwei
关键词:yak; lactate; lysine lactylation; metabolism; post-translational modification (PTM)
-
Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep
作者:Liang, Benmeng;Bai, Tianyou;Zhao, Yuhetian;Han, Jiangang;He, Xiaohong;Pu, Yabin;Ma, Yuehui;Jiang, Lin;Liang, Benmeng;Liu, Jianfeng;Liang, Benmeng;Liu, Jianfeng;Liang, Benmeng;Bai, Tianyou;Zhao, Yuhetian;Han, Jiangang;He, Xiaohong;Pu, Yabin;Ma, Yuehui;Jiang, Lin;Han, Jiangang;Wang, Chunxin;Liu, Wujun;Ma, Qing;Tian, Kechuan;Tian, Kechuan;Zheng, Wenxin;Liu, Nan
关键词:Chinese fine wool sheep; Whole genome sequencing; Genomic selection signature; Follicle density; Missense; Regulatory
-
A disposable immunosensor array using cellulose paper assembled chemiresistive biosensor for simultaneous monitoring of mycotoxins AFB1 and FB1
作者:He, Yue;Wang, Hui;Yu, Zhixue;Tang, Xiangfang;Zhou, Mengting;Xiong, Benhai;He, Yue;Guo, Yuming
关键词:Immunosensor; Mycotoxins; Paper-based biosensor; s-SWCNTs; Chemiresistive