Suppressive effects of aluminum trichloride on the T lymphocyte immune function of rats

文献类型： 外文期刊

第一作者： Zhu, Yanzhu

作者： Zhu, Yanzhu;Shao, Bing;Sun, Hao;Zhao, Hansong;Li, Yanfei;Zhu, Yanzhu;Hu, Chongwei;Li, Xinwei

作者机构：

关键词： Aluminum;T lymphocyte;T lymphocyte immune function;Rats

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2012 年 50 卷 3-4 期

页码：

收录情况： SCI

摘要： Aluminum (Al) has increasingly been used in the daily life, and could cause the change of human health because it can accumulate in the organs. A rat model was thus used to examine potential effect of Al on the immune function. Forty male Wistar rats (5 weeks old) weighed 110-120 g were randomly allocated into four groups and were orally exposed to 0, 64.18, 128.36, and 256.72 mg/kg body weight aluminum trichloride (AlCl3) in drinking water for 120 days. The levels of CD3(+), CD4(+), CD8(+) T lymphocyte, acid non-specific activity esterase (ANAE(+)) in blood, and interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in serum were determined at the end of experiment. The results showed that the proportions of CD3(+), CD4(+) T lymphocyte, the ratio of CD4(+)/CD8(+), and the levels of ANAE(+), IL-2, and TNF-alpha were significantly reduced in AlCl3-treated rats, while the proportion of CD8(+) T lymphocyte was increased in an AlCl3-dose dependent manner. Our findings indicate that a long term exposure of AlCl3 could suppress the T lymphocyte immune function of rats. (C) 2011 Elsevier Ltd. All rights reserved.

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