Clear Genetic Distinctiveness between Human- and Pig-Derived Trichuris Based on Analyses of Mitochondrial Datasets

文献类型： 外文期刊

第一作者： Liu, Guo-Hua

作者： Liu, Guo-Hua;Su, Ang;Xu, Min-Jun;Zhu, Xing-Quan;Liu, Guo-Hua;Zhu, Xing-Quan;Gasser, Robin B.;Su, Ang;Lin, Rui-Qing;Nejsum, Peter;Nejsum, Peter;Peng, Lifei;Li, Ming-Wei;Zhu, Xing-Quan

作者机构：

期刊名称：PLOS NEGLECTED TROPICAL DISEASES （ 影响因子：4.411； 五年影响因子：4.898 ）

ISSN： 1935-2727

年卷期： 2012 年 6 卷 2 期

页码：

收录情况： SCI

摘要： The whipworm, Trichuris trichiura, causes trichuriasis in similar to 600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of humans. Although Trichuris species are considered to be host specific, there has been considerable controversy, over the years, as to whether T. trichiura and T. suis are the same or distinct species. Here, we characterised the entire mitochondrial genomes of human-derived Trichuris and pig-derived Trichuris, compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. Taken together, the findings support the proposal that T. trichiura and T. suis are separate species, consistent with previous data for nuclear ribosomal DNA. Using molecular analytical tools, employing genetic markers defined herein, future work should conduct large-scale studies to establish whether T. trichiura is found in pigs and T. suis in humans in endemic regions.

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