Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus

文献类型： 外文期刊

第一作者： Pu Xiuying

作者： Pu Xiuying;Li Yan;Liang Jianping;Shang Ruofeng;Wang Xuehong;Liang Jianping;Zhou Liye

作者机构：

关键词： influenza A virus (IAV);Hypericum perforatum L. extract (HPE);therapeutic efficacy;cytokine

期刊名称：CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY （ 影响因子：2.273； 五年影响因子：2.45 ）

ISSN： 0008-4212

年卷期： 2012 年 90 卷 2 期

页码：

收录情况： SCI

摘要： Hypericum perforatum L., a plant used in Chinese herbal medicine, has been proven effective against many viral diseases. In the present study, the therapeutic efficacy of an extract of H. perforatum (HPE) against influenza A virus (IAV) was investigated in mice. Whether HPE would be a promising agent for influenza treatment was evaluated by measuring the protection rate, mean survival days, lung index, and viral titer, as well as the secretion of IL-6, interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in lung tissue and serum on days 3 and 5 post-infection. The results showed that HPE could reduce the lung index and viral titer of mice infected with IAV, decrease mortality, and prolong the mean survival time. HPE decreased the concentration of IL-6 and TNF-alpha in lung tissue and serum on day 5 post-infection. In contrast, HPE enhanced the lung and serum levels of IL-10 and IFN-gamma on the days 3 and 5 post-infection. Our study indicates that HPE has significant therapeutic efficacy for mice infected with IAV. The possible reasons for these results were concluded to be pertaining to up-regulating the expression of IL-10 and IFN-gamma, and down-regulating the secretion of IL-6 and TNF-alpha in lung and serum.

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