Characteristics of Nucleotide and Cod on Usage Bias of 2A Sequence of Foot and Mouth Disease Virus

文献类型： 外文期刊

第一作者： Gao, Zong-Liang

作者： Gao, Zong-Liang;Zhou, Jian-Hua;Ding, Yao-Zhong;Zhang, Jie;Chen, Hao-Tai;Ma, Li-Na;Liu, Yong-Sheng;Gu, Yuan-Xing

作者机构：

关键词： Foot and mouth disease virus;2A/2B junction;accumulation of codon bias;conformation change;co-translation

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2012 年 11 卷 19 期

页码：

收录情况： SCI

摘要： The cleavage at 2A/2B junction of Foot and Mouth Disease Virus (FM-DV) is mediated by the 2A sequence. Here researchers calculate some data of the 2A sequence including the nucleotide usage bias (R-value), the Authentic Codon Bias (ACB value) and accumulation of Codon Bias (CUB, value) to estimate potential effects of nucleotide and codon bias on the auto-cleavage of this junction Researchers find that a high nucleotide usage bias exists in the 2A sequence (R-value = 0.856 +/- 0.113), ten positions 3, 5, 8, 9, 11, 14-18 show a stable codon usage tendency in the 2A sequence across all serotype while the accumulation of Codon Bias (CUB2A = 0.293 +/- 0.043) is low. It is interesting that an obvious downward trend of accumulation of codon bias in C-termini is present in the 2A sequence. These phenomena suggest that the nucleotide and codon usage models play potential roles in impairing the formation of the peptide bond linking the 2A/2B junction during co-translation by affecting conformation changes of A and P sites in the ribosome.

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