Characterization and immunological evaluation of chitosan nanoparticles as adjuvants for bovine coronavirus N protein

文献类型： 外文期刊

第一作者： Yu, Li

作者： Yu, Li;Sun, Qingshen;Zhang, Jialing;Han, Dequan;Yang, Yongbo;Zhu, Li

作者机构：

关键词： chitosan nanoparticles;bovine coronavirus N protein;sustained release

期刊名称：ADVANCED MATERIALS AND ENGINEERING APPLICATIONS

ISSN： 1660-9336

年卷期： 2012 年 161 卷

页码：

收录情况： SCI

摘要： Chitosan nanoparticles (CNP) loaded with nucleocapsid protein of bovine coronavinis (BCV N) were prepared by ionic cross-linking method using sodium tripolyphosphate (TPP) as cross-linking agent. CNP loaded with BCV N protein was intramuscularly administered into Balb/c mice. Serum levels of anti-N protein IgG, IgM, and IgA antibodies were dynamically monitored by indirect ELISA method. Results showed that in the BCV N-loaded chitosan group, both IgA and IgG levels were found to increase significantly after the second immunization comparable to those of the Montanide ISA 206 groups. The IgM content in serum increased after the second immunization in the BCV N protein-loaded CNP group. These findings indicate that GNP can be used as adjuvant in veterinary vaccine field.

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