Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine

文献类型: 外文期刊

第一作者: Guo, Xiaoyu

作者: Guo, Xiaoyu;Hou, Shaohua;Zhu, Hongfei;Guo, Xiaoyu;Sanchez-Vizcaino, J. M.;Guo, Xiaoyu;Sanchez-Vizcaino, J. M.;Zhang, Quan;Zhai, Guoqin

作者机构:

关键词: Porcine reproductive and respiratory syndrome;CpG motif;Adjuvanticity;Immune response;Protection

期刊名称:VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY ( 影响因子:2.046; 五年影响因子:2.217 )

ISSN: 0165-2427

年卷期: 2011 年 144 卷 3-4 期

页码:

收录情况: SCI

摘要: Porcine reproductive and respiratory syndrome (PRRS) is now among the most important swine diseases that affect the Chinese swine industry. Both killed and live attenuated vaccines are currently used against the disease, but neither of them could provide full protection after vaccination. In the present study, the adjuvanticity of a plasmid containing CpG motifs (pUC18-CpG) was introduced to enhance the efficacy of a commercial PRRS live attenuated vaccine. After vaccination, PRRSV-specific antibodies, PRRSV-specific cytokines, and clinical parameters were studied and compared between different vaccinated groups. During a following challenge study, co-administration of pUC18-CpG with the vaccine could confer higher protection rate. Our results have shown that co-administration of pUC18-CpG with the vaccine could elicit more potent adaptive immune response and provide better protection. (C) 2011 Elsevier B.V. All rights reserved.

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