Research advances on flotillins

文献类型: 外文期刊

第一作者: Zhao, Feng

作者: Zhao, Feng;Zhang, Jie;Liu, Yong-Sheng;Li, Li;He, Ya-Li

作者机构:

关键词: Flotillin-1;Flotillin-2;Lipid raft;Signal transduction;Prion protein;GPI-anchored proteins

期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )

ISSN: 1743-422X

年卷期: 2011 年 8 卷

页码:

收录情况: SCI

摘要: The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well-conserved from fly to man, their exact functions remain controversial. In this review, we summarize the structure of flotillins and some functions of them, such as regulating axon regeneration, endocytosis, T cell activation, insulin signaling, membrane protein recruitment, roles in the progression of some diseases and so on.

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