A Determination of Potential alpha-Glucosidase Inhibitors from Azuki Beans (Vigna angularis)

文献类型： 外文期刊

第一作者： Yao, Yang

作者： Yao, Yang;Cheng, Xuzhen;Wang, Lixia;Wang, Suhua;Ren, Guixing

作者机构：

关键词： azuki beans;alpha-glucosidase inhibitory;vitexin;isovitexin

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2011 年 12 卷 10 期

页码：

收录情况： SCI

摘要： A 70% ethanol extract from azuki beans (Vigna angularis) was extracted further with CH2Cl2, EtOAc and n-BuOH to afford four fractions: CH2Cl2-soluble, EtOAc-soluble, n-BuOH-soluble and residual extract fractions. The EtOAc-soluble fractions showed the highest alpha-glucosidase inhibitory activity. Two pure flavonoid compounds, vitexin and isovitexin, were isolated (using the enzyme assay-guide fractionation method) from the EtOAc-soluble fractions. We further evaluated the interaction between the flavonoid compounds and alpha-glucosidase by fluorescence spectroscopy. Vitexin and isovitexin showed high inhibitory activities, with IC50 values of 0.4 mg.mL(-1) and 4.8 mg.mL(-1), respectively. This is the first study of the active compositions of azuki beans against alpha-glucosidase.

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