The codon usage model of the context flanking each cleavage site in the polyprotein of foot-and-mouth disease virus

文献类型: 外文期刊

第一作者: Zhou, Jian-hua

作者: Zhou, Jian-hua;Zhang, Jie;Chen, Hao-tai;Ma, Li-na;Ding, Yao-zhong;Liu, Yong-sheng;Pejsak, Zygmunt

作者机构:

关键词: Foot-and-mouth disease virus;Cleavage site;Codon usage pattern;The hosts

期刊名称:INFECTION GENETICS AND EVOLUTION ( 影响因子:3.342; 五年影响因子:3.188 )

ISSN: 1567-1348

年卷期: 2011 年 11 卷 7 期

页码:

收录情况: SCI

摘要: To investigate the codon usage pattern of the contexts flanking 11 cleavage sites of foot-and-mouth disease virus (FMDV) polyprotein, the codon usage model of the corresponding codon position and the synonymous codon usage in the target contexts of 66 strains were characterized by two simple methods based on the relative synonymous codon usage value. The synonymous codons usage pattern was also compared between this virus and two species of hosts (cattle and domestic pig). It is indicated that FMDV bore a general resemblance to the hosts in terms of the synonymous codon usage pattern. This feature may help FMDV to utilize translational resources of host efficiently. The two amino acid residues constituting each cleavage site contain at least one conserved residue. It was noticed that the codon usage model with the strong bias appeared in some specific positions in the target contexts, and the under-represented synonymous codons, AUA for Ile, CUA for Leu, UUA for Leu and GUA for Val, are preferentially used in these positions. These under-represented synonymous codons likely play role in regulating the translation rate and influencing the secondary structure of the contexts flanking the cleavage sites. (C) 2011 Elsevier B.V. All rights reserved.

分类号:

  • 相关文献

[1]Comparative the codon usage between the three main viruses in pestivirus genus and their natural susceptible livestock. Zhou, Jian-hua,Gao, Zong-liang,Zhang, Jie,Chen, Hao-tai,Ma, Li-na,Ding, Yao-zhong,Liu, Yong-sheng,Pejsak, Zygmunt. 2012

[2]Analysis of Synonymous Codon Usage in Dengue Viruses. Ma, Jun-Jun,Zhao, Feng,Zhang, Jie,Zhou, Jian-Hua,Ma, Li-Na,Ding, Yao-Zhong,Chen, Hao-Tai,Gu, Yuan-Xing,Liu, Yong-Sheng.

[3]The characteristics of the synonymous codon usage in enterovirus 71 virus and the effects of host on the virus in codon usage pattern. Liu, Yong-sheng,Zhou, Jian-hua,Chen, Hao-tai,Ma, Li-na,Ding, Yao-zhong,Zhang, Jie,Pejsak, Zygmunt.

[4]Proteolytic activation of Bacillus thuringiensis Vip3Aa protein by Spodoptera exigua midgut protease. Zhang, Ling,Xu, Lian,Li, Jie,Niu, Li -Yang,Chen, Qing-Xi,Pan, Zhi-Zhen,Liu, Bo,Chen, Zheng,Zhu, Yu-Jing. 2018

[5]Proteolytic Activation of Bacillus thuringiensis Cry2Ab through a Belt-and-Braces Approach. Xu, Lian,Zhang, Jing,Chen, Qing-Xi,Pan, Zhi-Zhen,Liu, Bo,Zhu, Yu-Jing.

[6]CpG DNA enhances the immune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs. Li, GJ,Li, YJ,Yan, WY,Xu, QX,Wu, YQ,Xie, Y,You, YJ,Zheng, ZX. 2001

[7]Enhanced immunogenicity of multiple-epitopes of foot-and-mouth disease virus fused with porcine interferon alpha in mice and protective efficacy in guinea pigs and swine. Du, Yijun,Li, Yufeng,Jiang, Wenming,Wang, Xinglong,Tang, Bo,Cao, Jun,Wang, Xianwei,Jian, Ping,He, Hairong,Qi, Jing. 2008

[8]Induction of Partial Protection against Foot and Mouth Disease Virus in Guinea Pigs by Neutralization with the Integrin beta 6-1 Subunit. Zhang, Yan,Sun, Yingjun,Yang, Fan,Guo, Jianhong,He, Jijun,Wu, Qiong,Cao, Weijun,Lv, Lv,Zheng, Haixue,Zhang, Zhidong. 2013

[9]Recovery of infectious foot-and-mouth disease virus from full-length genomic cDNA clones using an RNA polymerase I system. Chang, Yanyan,Zheng, Haixue,Shang, Youjun,Jin, Ye,Wang, Guangxiang,Shen, Xiaoyan,Liu, Xiangtao. 2009

[10]Development and validation of a lateral flow immunoassay using colloidal gold for the identification of serotype-specific foot-and-mouth disease virus O, A and Asia 1. Jiang, Tao,Liang, Zhong,Ren, Weiwei,Chen, Juan,Zhi, Xiaoying,Qi, Guangyu,Yang, Yamin,Liu, Zaixing,Liu, Xiangtao,Cai, Xuepeng,Ren, Weiwei,Zhi, Xiaoying,Qi, Guangyu. 2011

[11]An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo. Zeng, Jianxiong,Wang, Haiwei,Xie, Xiaochun,Yang, Decheng,Zhou, Guohui,Yu, Li.

[12]Induction of systemic IFITM3 expression does not effectively control foot-and-mouth disease viral infection in transgenic pigs. Zhang, Huawei,Qian, Ping,Xu, Jinfang,Yang, Xi,Zhou, Rui,Chen, Huanchun,Li, Xiangmin,Zhang, Huawei,Qian, Ping,Xu, Jinfang,Yang, Xi,Zhou, Rui,Chen, Huanchun,Li, Xiangmin,Zheng, Haixue.

[13]Foot-and-mouth disease virus VP1 protein fused with cholera toxin B subunit expressed in Chlamydomonas reinhardtii chloroplast. Sun, M,Qian, KX,Su, N,Chang, HY,Liu, JX,Chen, GF.

[14]Construction and characterization of 3A-epitope-tagged foot-and-mouth disease virus. Ma, Xueqing,Li, Pinghua,Sun, Pu,Bai, Xingwen,Bao, Huifang,Lu, Zengjun,Fu, Yuanfang,Cao, Yimei,Li, Dong,Chen, Yingli,Liu, Zaixin,Qiao, Zilin.

[15]Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication. Li, Chuntian,Zhu, Zixiang,Du, Xiaoli,Cao, Weijun,Yang, Fan,Zhang, Xiangle,Feng, Huanhuan,Li, Dan,Zhang, Keshan,Liu, Xiangtao,Zheng, Haixue.

[16]Purification of foot-and-mouth disease virus by heparin as ligand for certain strains. Du, Ping,Sun, Shiqi,Dong, Jinjie,Zhi, Xiaoying,Chang, Yanyan,Teng, Zhidong,Guo, Huichen,Liu, Zaixin.

[17]Cross-protective efficacy of engineering serotype A foot-and-mouth disease virus vaccine against the two pandemic strains in swine. Zheng, Haixue,Lian, Kaiqi,Yang, Fan,Jin, Ye,Zhu, Zixiang,Guo, Jianhong,Cao, Weijun,Liu, Huanan,He, Jijun,Zhang, Keshan,Li, Dan,Liu, Xiangtao.

[18]Characteristics of codon usage bias in two regions downstream of the initiation codons of foot-and-mouth disease virus. Zhou, Jian-hua,Zhang, Jie,Ding, Yao-zhong,Chen, Hao-tai,Ma, Li-na,Liu, Yong-sheng.

[19]Effect of the nucleotides surrounding the start codon on the translation of foot-and-mouth disease virus RNA. Ma, X. X.,Feng, Y. P.,Ma, Z. R.,Gu, Y. X.,Ma, X. X.,Zhou, J. H..

[20]Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs. Cao, Yimei,Lu, Zengjun,Sun, Jiachuan,Bai, Xingwen,Sun, Pu,Bao, Huifang,Chen, Yingli,Guo, Jianhong,Li, Dong,Liu, Xiangtao,Liu, Zaixin.

作者其他论文 更多>>