Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (-)-epigallocatechin gallate for enhancing the effectiveness against UVB-induced skin damage

文献类型： 外文期刊

第一作者： Zhang, Weihua

作者： Zhang, Weihua;Yang, Yuanyuan;Lv, Tao;Fan, Zhaoyang;Liao, Bingwu;Ying, Hao;Ravichandran, Nagaiya;Du, Qizhen;Xu, Yongquan;Yin, Junfeng

作者机构：

关键词： sucrose esters;degree of esterification;nanoethosomes;stabilization;(-)-epigallocatechin gallate

期刊名称：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS （ 影响因子：3.368； 五年影响因子：3.402 ）

ISSN： 1552-4973

年卷期： 2017 年 105 卷 8 期

页码：

收录情况： SCI

摘要： Nanoethosomal suspensions, composed of phospholipids, ethanol, and water, are novel lipid carriers. These suspensions have been reported to enhance the permeation of drugs into the skin as a result of the interdigitation effect of ethanol on the lipid bilayer of liposomes and by increasing the fluidity of lipids in the stratum corneum. The physical stability of the nanoethosomal suspension is still a critical research problem until now. This study investigated the commercial palm sucrose esters to improve the colloidal stability of nanoethosomal suspensions. The results indicated that palm sucrose esters (PSE) were effective for stabilizing nanoethosomal suspension of (-)-epigallocatechin gallate (EGCG) from green tea. A PSE concentration of 0.15% was optimal for a nanoethosomal suspension which gave mean diameter 75.5 +/- 3.5 nm, zeta potential -30.8 +/- 3.2 mV and polydispersity index 0.207 +/- 0.017. Moreover, the effectiveness of stabilization was influenced by the degree of esterification of the sucrose esters: the sucrose polyesters could prolong the stability of nanoethosomes loaded with EGCG to a year, but the sucrose monoesters only provided less than 6 months of stabilization. EGCG nanoethosomal suspension stabilized by sucrose polyesters shows better inhibition effectiveness against UVB-induced skin damage than native EGCG. The nanoethosomal suspension has the potential for its utilization as skin care and other products. (C) 2016 Wiley Periodicals, Inc.

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