Uncovering the embryonic developmentrelated proteome and metabolome signatures in breast muscle and intramuscular fat of fast-and slow-growing chickens

文献类型： 外文期刊

第一作者： Liu, Ranran

作者： Liu, Ranran;Wang, Hongyang;Liu, Jie;Wang, Jie;Zheng, Maiqing;Tan, Xiaodong;Xing, Siyuan;Cui, Huanxian;Li, Qinghe;Zhao, Guiping;Wen, Jie;Liu, Ranran;Wang, Hongyang;Liu, Jie;Wang, Jie;Zheng, Maiqing;Tan, Xiaodong;Xing, Siyuan;Cui, Huanxian;Li, Qinghe;Zhao, Guiping;Wen, Jie

作者机构：

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2017 年 18 卷

页码：

收录情况： SCI

摘要： Background: Skeletal muscle development is closely linked to meat production and its quality. This study is the first to quantify the proteomes and metabolomes of breast muscle in two distinct chicken breeds at embryonic day 12 (ED 12), ED 17, post-hatch D 1 and D 14 using mass spectrometry-based approaches. Results: Results found that intramuscular fat (IMF) accumulation increased from ED 17 to D 1 and that was exactly the opposite of when most obvious growth of muscle occurred (ED 12 - D 17 and D 1 - D 14). For slow-growing Beijing-You chickens, Ingenuity Pathway Analysis of 77-99 differential abundance (DA) proteins and 63-72 metabolites, indicated significant enrichment of molecules and pathways related to protein processing and PPAR signaling. For fast-growing Cobb chickens, analysis of 68-95 DA proteins and 56-59 metabolites demonstrated that molecules and pathways related to ATP production were significantly enriched after ED12. For IMF, several ratelimiting enzymes for beta-oxidation of fatty acid (ACADL, ACAD9, HADHA and HADHB) were identified as candidate biomarkers for IMF deposition in both breeds. Conclusions: This study found that ED 17 - D 1 was the earliest period for IMF accumulation. Pathways related to protein processing and PPAR signaling were enriched to support high capacity of embryonic IMF accumulation in Beijing-You. Pathways related to ATP production were enriched to support the fast muscle growth in Cobb. The beta-oxidation of fatty acid is identified as the key pathway regulating chicken IMF deposition at early stages.

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