MicroRNA-126 participates in lipid metabolism in mammary epithelial cells

文献类型: 外文期刊

第一作者: Chu, Meiqiang

作者: Chu, Meiqiang;Zhao, Yong;Feng, Yanni;Li, Lan;Shen, Wei;Min, Lingjiang;Zhang, Hongfu;Liu, Jing;Cheng, Ming;Cao, Hongfang;Li, Qiang

作者机构:

关键词: MicroRNA-126-3p;Mammary luminal epithelial cells;Lipid metabolism;Estradiol;Progesterone

期刊名称:MOLECULAR AND CELLULAR ENDOCRINOLOGY ( 影响因子:4.102; 五年影响因子:4.226 )

ISSN: 0303-7207

年卷期: 2017 年 454 卷 C 期

页码:

收录情况: SCI

摘要: Lipids are a major component of milk and are important for infant growth and development. MicroRNA-126 (miR-126) has previously been observed in mammary glands and adipocytes and is known to be involved in lipid metabolism during the process of atherosclerosis. However, it remains unknown whether miR-126 also participates in lipid metabolism in mammary luminal epithelial cells (MECs). In the current investigation, miR-126-3p inhibition stimulated lipid synthesis in MECs in part through increasing levels of the lipid synthesis enzymes FASN, ACSL1, and Insig1. Overexpression of miR-126-3p decreased lipid content in MECs with a reduction in FASN and Insig1. Furthermore, the expression of miR-126-3p was diminished by the steroid hormones estradiol and progesterone with a subsequent elevation of lipid formation in MECs. We also noted that miR-126-3p was expressed differentially at various stages of murine mammary gland development, exhibiting a negative correlation with FASN. Together these findings suggest that miR-126-3 might be involved in lipid metabolism in mammary gland. (C) 2017 Elsevier B.V. All rights reserved.

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