Sex-specific effects of difenoconazole on the growth hormone endocrine axis in adult zebrafish (Danio rerio)

文献类型: 外文期刊

第一作者: Teng, Miaomiao

作者: Teng, Miaomiao;Zhu, Wentao;Wang, Yao;Wang, Dezhen;Yang, Yang;Li, Hui;Li, Chenglong;Wang, Chengju;Qi, Suzhen;Dong, Kai

作者机构:

关键词: Difenoconazole;Zebrafish;GH/IGF axis;Growth endocrine;Sex-specific

期刊名称:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY ( 影响因子:6.291; 五年影响因子:6.393 )

ISSN: 0147-6513

年卷期: 2017 年 144 卷

页码:

收录情况: SCI

摘要: Difenoconazole, as one of the most widely used triazole fungicides, is applied to protect crops, fruits, and vegetables. It has been reported that difenoconazole can enter the environment and impair aquatic organisms, but whether difenoconazole can disrupt the growth hormone (GH) balance in adult zebrafish (Danio rerio) is still unclear. In this study, adult female and male zebrafish were exposed to difenoconazole (0, 5, 50, and 500 mu g/L) for seven days. The results revealed that the bioaccumulation of difenoconazole and its primary metabolite difenoconazole alcohol in females were both larger than that in males. In females, the growth of the liver and ovary were inhibited, which may be due to the decreased transcription of the key genes igf1a, igf2a, and igf2b in both organs. Male fish growth was promoted in response to the increased expression of genes relevant to the GH/insulin-like growth factor axis (GH/IGF) axis in the brain, liver, and testis as well as increased GH levels. It was found that difenoconazole interfered with the growth endocrine system and sex-specifically altered the expression of GH/IGF axis related genes in adult zebrafish after a short-term exposure.

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