Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus

文献类型: 外文期刊

第一作者: Ma, Yong

作者: Ma, Yong;Sun, Jiashan;Gu, Linlin;Bao, Hongmei;Zhao, Yuhui;Tian, Guobin;Wang, Xiurong;Chen, Hualan;Shi, Lin;Yao, Wei

作者机构:

关键词: H5N1 subtype HPAIV;NS1;ANXA2;Viral replication

期刊名称:BMC MICROBIOLOGY ( 影响因子:3.605; 五年影响因子:4.283 )

ISSN: 1471-2180

年卷期: 2017 年 17 卷

页码:

收录情况: SCI

摘要: Background: Non-structural protein 1 (NS1) is a multifunctional protein and a crucial regulatory factor in the replication and pathogenesis of avian influenza virus (AIV). Studies have shown that NS1 can interact with a variety of host proteins to modulate the viral life cycle. We previously generated a monoclonal antibody against NS1 protein; In the current research study, using this antibody, we immunoprecipitated host proteins that interact with NS1 to better understand the roles played by NS1 in communications between virus and host. Results: Co-immunoprecipitation experiments identified annexin A2 (ANXA2) as a target molecule interacting with NS1. Results from confocal laser scanning microscopy indicated that NS1 co-localized with ANXA2 in the cell cytoplasm. Overexpression of ANXA2 significantly increased the titer of H5N1 subtype HPAIV, whereas siRNA-mediated knockdown of ANXA2 markedly inhibited the expression of viral proteins and reduced the progeny virus titer. Conclusions: Our results indicate that ANXA2 interacts with NS1 and ANXA2 expression increases HPAIV replication.

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