Structure elucidation and toxicity analyses of the radiolytic products of aflatoxin B-1 in methanol-water solution

文献类型： 外文期刊

第一作者： Wang, Feng

作者： Wang, Feng;Xie, Fang;Wang, Zhidong;Fan, Bei;Ha, Yiming;Wang, Feng;Xie, Fang;Wang, Zhidong;Fan, Bei;Ha, Yiming;Wang, Feng;Xue, Xiaofeng

作者机构：

关键词： Aflatoxin B-1;Radiolytic products;LC-Q-TOF MS;Structure;Toxicity

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2011 年 192 卷 3 期

页码：

收录情况： SCI

摘要： The identification of the radiolytic products of mycotoxins is a key issue in the feasibility study of gamma ray radiation detoxification. Methanol-water solution (60:40, v/v) spiked with aflatoxin B-1 (AFB(1); 20 mg L-1) was irradiated with Co-60 gamma ray to generate radiolytic products. Liquid chromatography-quadruple time-of-flight mass spectrometry was applied to identify the radiolytic products of AFB1. Accurate mass and proposed molecular formulas with a high-matching property of more than 20 radiolytic products were obtained. Seven key radiolytic products were proposed based on the molecular formulas and tandem mass spectrometry spectra. The analyses of toxicity and formation pathways were proposed based on the structure of the radiolytic products. The addition reaction caused by the free-radical species in the methanol-water solution resulted in the formation of most radiolytic products. Based on the structure-activity relationship analysis, the toxicity of radiolytic products was significantly reduced compared with that of AFB(1) because of the addition reaction that occurred on the double bond in the terminal furan ring. For this reason, gamma irradiation is deemed an effective tool for the detoxification of AFB(1). (C) 2011 Elsevier B.V. All rights reserved.

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