Caspase- and p38-MAPK-dependent induction of apoptosis in A549 lung cancer cells by Newcastle disease virus

文献类型： 外文期刊

第一作者： Bian, Jianchun

作者： Bian, Jianchun;Chen, Fei;Hu, Maozhi;Zhang, Xiaorong;Jiao, Xinan;Wu, Yantao;Meng, Songshu;Bian, Jianchun;Kong, Xiangang;Liu, Huairan;Meng, Songshu;Wang, Kai;Ge, Baoxue

作者机构：

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2011 年 156 卷 8 期

页码：

收录情况： SCI

摘要： Newcastle disease virus (NDV) has a potential oncolytic effect due to its ability to induce apoptosis in tumor cells. However, previous studies have indicated discrepancies regarding the apoptosis signaling pathways induced by NDV in tumor cells. Here, we show that NDV infection induces simultaneous activation of intrinsic and extrinsic death pathways in A549 human lung cancer cells. In contrast, endoplasmic reticulum (ER) stress is not activated in NDV-induced apoptosis. We demonstrate for the first time that mitogen-activated protein kinase (MAPK) pathways are activated in NDV-infected A549 cells, and p38 MAPK is involved in NDV-induced cell death. Together, our findings provide novel insights into the underlying mechanisms by which NDV induces apoptosis in tumor cells.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序