Induction of heme oxygenase-1 with beta-CD-hemin complex mitigates cadmium-induced oxidative damage in the roots of Medicago sativa

文献类型： 外文期刊

第一作者： Fu, Guangqing

作者： Fu, Guangqing;Cui, Weiti;Wang, Yanqin;Shen, Wenbiao;Zhang, Liefeng;Ren, Yong;Zheng, Tianqing

作者机构：

关键词： beta-CD-hemin;Cadmium-induced oxidative damage;GSH;Heme oxygenase-1;Medicago sativa

期刊名称：PLANT AND SOIL （ 影响因子：4.192； 五年影响因子：4.712 ）

ISSN： 0032-079X

年卷期： 2011 年 345 卷 1-2 期

页码：

收录情况： SCI

摘要： Using pharmacological and biochemical approaches, the functional roles of heme oxygenase-1 (HO-1) induction in cadmium (Cd)-stressed alfalfa (Medicago sativa) seedling roots caused by a metal-organic complex (beta-cyclodextrin-hemin, beta-CD-hemin, CDH) and the well-known HO-1 inducer hemin, were investigated and compared. Cd-stressed seedling roots exhibited severe oxidative damage, whereas up-regulation of HO-1 by CDH and hemin pretreatment prevented this toxic response, as evidenced by the decrease of lipid peroxidation as well as the alleviation of growth inhibition and Cd accumulation. Reestablishment of glutathione (GSH) and reactive oxygen species (ROS) homeostasis were observed. Upon Cd stress, 0.01 mu M CDH and 10 mu M hemin pretreatment alleviated lipid peroxidation to almost the same extent and the CDH was highly potent. The modulation of the transcripts and total activities of ascorbate peroxidase (APX) and superoxide dismutase (SOD) were regulated by CDH and hemin, respectively. We also noticed that the potent HO-1 inhibitor zinc protoporphyrin IX (ZnPP) significantly reversed the CDH-driven cytoprotective roles. Additionally, beta-CD was found to be ineffective in the alleviation of lipid peroxidation. Taken together, the data suggested that HO-1 induction mediated by CDH provides critical protection against Cd-induced oxidative damage and toxicity partly by lowering the Cd accumulation.

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