Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep

文献类型： 外文期刊

第一作者： Chu, Mingxing

作者： Chu, Mingxing;Fang, Li;Di, Ran;Cao, Guiling;Feng, Tao;Tang, Qianqian;Ma, Yuehui;Li, Kui;Jia, Lihua;Chen, Hongquan;Zhang, Yingjie;Jin, Mei

作者机构：

关键词： Bone morphogenetic protein receptor IB gene;PCR-SSCP;Prolificacy;Sheep

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

ISSN： 0301-4851

年卷期： 2011 年 38 卷 6 期

页码：

收录情况： SCI

摘要： The bone morphogenetic protein receptor IB (BMPR-IB) was studied as a candidate gene for the prolificacy of sheep. Nine pairs of primers (P1-P9) were designed to detect single nucleotide polymorphisms (SNPs) of exons 1-4 and 6-10 of the BMPR-IB gene in both high (Small Tail Han and Hu sheep) and low prolificacy breeds (Texel and Chinese Merino sheep) by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP). Only the products amplified by primers P2, P5, P6, P7, P8 and P9 displayed polymorphisms. The present study identified 22 SNPs in partial coding regions of ovine BMPR-IB, in which 20 SNPs were reported for the first time. In total of the 22 mutations, 18 DNA variations were originated from the Hu breed, three were found in the Small Tail Han breed (two of them were found in other sheep breeds), three in the Chinese Merino breed, and none in the Texel breed. These results preliminarily demonstrated that BMPR-IB is a major gene affecting the hyperprolificacy in Small Tail Han and Hu sheep, and could be used as a molecular genetic marker for early auxiliary selection for hyperprolificacy in sheep.

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