Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light

文献类型: 外文期刊

第一作者: Liu, Bin

作者: Liu, Bin;Zuo, Zecheng;Liu, Hongtao;Lin, Chentao;Liu, Bin;Zuo, Zecheng;Liu, Xuanming

作者机构:

关键词: blue-light receptor;cryptochrome;E3 ubiquitin ligase;protein degradation;photomorphogenesis

期刊名称:GENES & DEVELOPMENT ( 影响因子:11.361; 五年影响因子:12.029 )

ISSN: 0890-9369

年卷期: 2011 年 25 卷 10 期

页码:

收录情况: SCI

摘要: Plant photoreceptors mediate light suppression of the E3 ubiquitin ligase COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) to affect gene expression and photomorphogenesis. However, how photoreceptors mediate light regulation of COP1 activity remains unknown. We report here that Arabidopsis blue-light receptor cryptochrome 1 (CRY1) undergoes blue-light-dependent interaction with the COP1-interacting protein SPA1 (SUPPRESSOR OF PHYTOCHROME A). We further show that the CRY1-SPA1 interaction suppresses the SPA1-COP1 interaction and COP1-dependent degradation of the transcription factor HY5. These results are consistent with a hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity and plant development.

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