Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis

文献类型： 外文期刊

第一作者： Li, Jigang

作者： Li, Jigang;Lau, On-Sun;Ouyang, Xinhao;Dai, Mingqiu;Deng, Xing Wang;Wang, Haiyang;Siddiqui, Hamad;Devlin, Paul F.;Teng, Yibo;Lin, Rongcheng;Wan, Xiang-yuan;Deng, Xing Wang;Wang, Haiyang;Wan, Jianmin;Wang, Haiyang;Wang, Haiyang

作者机构：

期刊名称：NATURE CELL BIOLOGY （ 影响因子：28.824； 五年影响因子：26.648 ）

ISSN： 1465-7392

年卷期： 2011 年 13 卷 5 期

页码：

收录情况： SCI

摘要： The circadian clock controls many metabolic, developmental and physiological processes in a time-of-day-specific manner in both plants and animals(1,2). The photoreceptors involved in the perception of light and entrainment of the circadian clock have been well characterized in plants(3). However, how light signals are transduced from the photoreceptors to the central circadian oscillator, and how the rhythmic expression pattern of a clock gene is generated and maintained by diurnal light signals remain unclear. Here, we show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive regulators of the phytochrome A signalling pathway, directly bind to the promoter of ELF4, a proposed component of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these transcription-promoting factors. Our findings provide evidence that a set of light- and circadian-regulated transcription factors act directly and coordinately at the ELF4 promoter to regulate its cyclic expression, and establish a potential molecular link connecting the environmental light dark cycle to the central oscillator.

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