Effect of streptozocin-induced diabetes mellitus on expression of methionine sulfoxide reductases and accumulation of their substrates in mouse lenses
文献类型: 外文期刊
第一作者: Li, Yi
作者: Li, Yi;Huang, Kaixun;Zhang, Wen;Li, Peiwu
作者机构:
关键词: cataract;streptozotocin;diabetes;methionine sulfoxide reductase;oxidative stress;lens
期刊名称:EXPERIMENTAL EYE RESEARCH ( 影响因子:3.467; 五年影响因子:3.811 )
ISSN: 0014-4835
年卷期: 2011 年 92 卷 5 期
页码:
收录情况: SCI
摘要: To determine the influences of early-stage diabetes mellitus on methionine sulfoxide reductases (Msrs) expression in lenses, streptozocin (STZ)-induced diabetic mice as animal models were used in this study. The results showed that the contents of methionine sulfoxide (MetO), protein carbonyl (PC) and Malondialdehyde (MDA) in the lenses of STZ-induced diabetic mice after 14 days were significantly higher than that in the normal control, level of total sulfhydryl groups (TSH) was 60% of normal control, and mRNA expressing levels of the MsrA and MsrBs were significantly decreased compared with normal group, as was the expression of MsrB1 protein. These results suggest that STZ not only causes increased oxidative stress, but also suppresses Msr mRNA and MsrB1 protein expression during early-stage diabetes in mice. However, the mechanism remains to research. (c) 2011 Elsevier Ltd. All rights reserved.
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