Hollow mesoporous silica nanoparticles for intracellular delivery of fluorescent dye

文献类型： 外文期刊

第一作者： Guo, Huichen

作者： Guo, Huichen;Sun, Shiqi;Sun, Dehui;Yin, Hong;Cai, Xuepeng;Liu, Zaixin;Wu, Jinyan;Jiang, Tao;Liu, Xiangtao;Guo, Huichen;Sun, Shiqi;Sun, Dehui;Yin, Hong;Cai, Xuepeng;Liu, Zaixin;Wu, Jinyan;Jiang, Tao;Liu, Xiangtao;Qian, Haisheng

作者机构：

期刊名称：CHEMISTRY CENTRAL JOURNAL （ 影响因子：4.215； 五年影响因子：3.836 ）

ISSN： 1752-153X

年卷期： 2011 年 5 卷

页码：

收录情况： SCI

摘要： In this study, hollow mesoporous silica nanoparticles (HMSNs) were synthesized using the sol-gel/emulsion approach and its potential application in drug delivery was assessed. The HMSNs were characterized, by transmission electron microscopy (TEM), Scanning Electron Microscopy (SEM), nitrogen adsorption/desorption and Brunauer-Emmett-Teller (BET), to have a mesoporous layer on its surface, with an average pore diameter of about 2 nm and a surface area of 880 m(2)/g. Fluorescein isothiocyanate (FITC) loaded into these HMSNs was used as a model platform to assess its efficacy as a drug delivery tool. Its release kinetic study revealed a sequential release of FITC from the HMSNs for over a period of one week when soaked in inorganic solution, while a burst release kinetic of the dye was observed just within a few hours of soaking in organic solution. These FITC-loaded HMSNs was also found capable to be internalized by live human cervical cancer cells (HeLa), wherein it was quickly released into the cytoplasm within a short period of time after intracellular uptake. We envision that these HMSNs, with large pores and high efficacy to adsorb chemicals such as the fluorescent dye FITC, could serve as a delivery vehicle for controlled release of chemicals administered into live cells, opening potential to a diverse range of applications including drug storage and release as well as metabolic manipulation of cells.

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