Polymorphisms of the cocaine-amphetamine-regulated transcript (CART) gene and their association with reproductive traits in Chinese goats

文献类型： 外文期刊

第一作者： Wang, P. Q.

作者： Wang, P. Q.;Deng, L. M.;Zhang, B. Y.;Chu, M. X.;Hou, J. Z.

作者机构：

关键词： CART gene;SNPs;Microsatellites;Reproduction traits;Goats

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2011 年 10 卷 2 期

页码：

收录情况： SCI

摘要： Polymorphisms of the CART gene were investigated by PCR-single-strand conformation polymorphism analysis in 540 samples from 10 goat breeds. Ten novel single-nucleotide polymorphisms as well as three microsatellites were detected; a mutation, 77T -> C, led to an amino acid change (Leu -> Ser). Associations between polymorphic loci and reproductive traits were analyzed in Chuandong White, Guizhou White and Gulin Ma breeds. Mutation at position 524 had no significant effect on litter size in these three goat breeds. The polymorphism 539C -> A differed significantly among the three breeds (P < 0.05); C(7)T(8)/C(9)T(8) at 939 was associated with larger litter size (P < 0.05) than genotypes C(7)T(8)/C(7)T(8) and C(7)T(8)/C(8)T(8). No significant association of birth weight was found with gene variation (524C -> T, 539C -> A and 939 C(n)T(n)). These findings could be valuable for marker-assisted selection for goat breeding.

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