Comparative Mapping and 3 ' UTR SNP Detection of ANGPTL4 Gene in Beef Cattle

文献类型： 外文期刊

第一作者： Ma, Y.

作者： Ma, Y.;Li, R. R.;Hou, F.;Zhang, Y. H.;Chen, H.;Ma, Y.;Xu, S. Z.;Cheng, N.

作者机构：

关键词： Cattle;ANGPTL4 gene;RH;SNP;IMF;China

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2011 年 10 卷 13 期

页码：

收录情况： SCI

摘要： Angiopoietin-like 4 (ANGPTL4), a member of the angiopoietin-like gene family, encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain which is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. ANGPTL4 is a serum hormone directly involved in regulating angiogenesis, lipid metabolism, glucose metabolism, cancer and metabolic diseases. In this study, Radiation Hybrid (RH) cloning board technique, PCR-SSCP and DNA sequencing methods were employed to map bovine ANGPTL4 gene and examine the single nucleotide polymorphisms (SNPs) at the 3'UTR of this gene in 281 cattle from seven breeds. Here, the bovine ANGPTL4 gene was located between the framework marker CA006 and DIK4204 on BTA7 with a map distance of 2.33 cR to the former and an interval of 8.54 cR to the latter. A novel mutation (NC_007305.3: g.C6640T) was revealed which constructed three genotypes (CC, CT and TT). This locus proved to be significantly associated with Average Daily Gain (ADG), Rib-eye Area (REA), Intramuscular Fat (IMF) (p<0.05) and Beef Performance Index (BPI) (p<0.01) in the analyzed populations. Meanwhile, individuals with genotype TT were significantly higher than those with CC in BPI, ADO and REA while it was reversed for genotype TT and CC in the IMF which proved that bovine ANGPTL4 gene had a positive effect on production traits, Hence, genotype TT and CC could be regarded as molecular markers for BPI, ADG and REA and IMF, respectively.

分类号：

  • 相关文献

[1]Polymorphisms in MC4R gene and correlations with economic traits in cattle. Huang, Meng,Xu, Shang Zhong,Huang, Meng,Gao, Xue,Li, Jun Ya,Ren, Hong Yan,Chen, Jin Bao,Xu, Shang Zhong.

[2]Association of CAST gene polymorphisms with carcass and meat quality traits in Yanbian cattle of China. Li, Y. X.,Seo, K. S.,Jin, H. G.,Zhang, L. C.,Yan, C. G.,Ren, C. Y.,Jin, X..

[3]Molecular characterization, expression pattern, polymorphism and association analysis of bovine ADAMTSL3 gene. Liu, Yongfeng,Zan, Linsen,Zhao, Shuanping,Xin, Yaping,Jiao, Yang,Zhao, Shuanping,Li, Kui,Liu, Yongfeng.

[4]Correlation analysis between three novel SNPs of the Src gene in bovine and milk production traits. Liu, Wenyan,Wang, Ji,Li, Qiuling,Ju, Zhihua,Huang, Jinming,Wang, Hongmei,Li, Jianbin,Zhong, Jifeng,Wang, Changfa,Liu, Wenyan,Liu, Shunde.

[5]Single Nucleotide Polymorphism (SNP) Analysis of orexin Gene 5 ' Regulatory Region in Chinese Indigenous Cattle Populations. Zhang Ai-ling,Zhang Li,Zhang Liang-zhi,Lan Xian-yong,Zhang Cun-fang,Chen Hong,Zhang Ai-ling,Zhang Li,Zhang Cun-lei,Chen Hong. 2011

[6]Evaluating the Babesia bovis infection of cattle in China with enzyme-linked immunosorbent assay (ELISA). Yang, Congshan,Liu, Junlong,Li, Anyan,Li, Youquan,Liu, Aihong,Xie, Junren,Liu, Guangyuan,Yin, Hong,Guan, Guiquan,Luo, Jianxun,Yin, Hong,Luo, Jianxun.

[7]Insight into the genetic diversity of Anaplasma marginale in cattle from ten provinces of China. Yang, Jifei,Han, Rong,Liu, Zhijie,Niu, Qingli,Guan, Guiquan,Liu, Guangyuan,Luo, Jianxun,Yin, Hong,Yin, Hong. 2017

[8]Rumen ciliated protozoan fauna of the yak (Bos grunniens) in China with the description of Entodinium monuo n. sp.. Guirong,Su, NR,Hua, ZX,Zhu, S,Imai, SC.

[9]Phylogenetic Analysis of Ruminant Theileria spp. from China Based on 28S Ribosomal RNA Gene. Gou, Huitian,Guan, Guiquan,Ma, Miling,Liu, Aihong,Liu, Zhijie,Xu, Zongke,Ren, Qiaoyun,Li, Youquan,Yang, Jifei,Chen, Ze,Yin, Hong,Luo, Jianxun.

[10]A history of the prevalence and control of contagious bovine pleuropneumonia in China. Xin, Jiuqing,Li, Yuan,Nicholas, Robin A. J.,Chen, Chao,Liu, Yang,Zhang, Mei-jing,Dong, Hui. 2012

[11]Effects of breed, postnatal development, and nutrition on mRNA expression of the FTO gene in porcine muscle and its relationship with intramuscular fat deposition. Tao, X.,Men, X. M.,Deng, B.,Xu, Z. W..

[12]Genetic differentiation in seven geographic populations of the fleshy shrimp Penaeus (Fenneropenaeus) chinensis based on microsatellite DNA. Meng, Xian Hong,Wang, Qing Yin,Liu, Ping,Kong, Jie,Meng, Xian Hong,Jang, In Kwon.

[13]Evaluating agricultural catastrophic risk. Xu, Lei,Zhang, Qiao,Xu, Lei,Zhang, Qiao,Zhang, Xi. 2011

[14]Construction of a Genetic Linkage Map and Mapping of a Female-Specific DNA Marker in Half-Smooth Tongue Sole (Cynoglossus semilaevis). Liao, Xiaolin,Ma, Hong-Yu,Xu, Gen-Bo,Shao, Chang-Wei,Tian, Yong-Sheng,Ji, Xiang-Shan,Yang, Jing-Feng,Chen, Song-Lin.

[15]Assessment of the local environmental impact of intensive marine shellfish and seaweed farming-Application of the MOM system in the Sungo Bay, China. Zhang, Jihong,Fang, Jianguang,Wang, Wei,Jiang, Zengjie,Zhang, Jihong,Fang, Jianguang,Wang, Wei,Jiang, Zengjie,Hansen, Pia Kupka.

[16]A SNP in intron 8 of CD46 causes a novel transcript associated with mastitis in Holsteins. Wang, Xiuge,Zhong, Jifeng,Gao, Yundong,Ju, Zhihua,Huang, Jinming,Huang, Jinming. 2014

[17]Variants and Gene Expression of the TLR2 Gene and Susceptibility to Mastitis in Cattle. Huang, Jinming,Liu, Li,Wang, Hongmei,Zhang, Cuixia,Ju, Zhihua,Wang, Changfa,Zhong, Jifeng.

[18]Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of the BOLA-DQA2 Gene in Dairy Cattle. Hou, Qinlei,Huang, Jinming,Ju, Zhihua,Li, Qiuling,Li, Liming,Wang, Changfa,Sun, Tao,Wang, Lingling,Hou, Minghai,Zhong, Jifeng,Hang, Suqin.

[19]Identification of differentially expressed proteins between bull X and Y spermatozoa. Chen, Xiaoli,Zhu, Huabin,Hao, Haisheng,Zhao, Xueming,Du, Weihua,Qin, Tong,Liu, Yan,Wang, Dong,Chen, Xiaoli,Wu, Chengjiang,Han, Weidong. 2012

[20]Protecting Local Breeds of Livestock in NW China. Lang Xia,Wang Cailian,Squires, Victor. 2010

作者其他论文 更多>>

微信小程序