Validated hydrophilic interaction LC-MS/MS method for determination of N-methyl-2-pyrrolidinone residue. Applied to a depletion study of N-methyl-2-pyrrolidinone in swine liver following intramuscular administration of drug N-methyl-2-pyrrolidinone formulation

文献类型： 外文期刊

第一作者： Liu, Yanhong

作者： Liu, Yanhong;Ji, Yanhong;Chen, Jingtao;Chen, Ximing;Wang, Guangxiang;Shang, Youjun;Liu, Xiangtao;Pan, Jack

作者机构：

关键词： N-methyl-2-pyrrolidinone;C18+WAX;LC-MS/MS;Matrix effect

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.205； 五年影响因子：3.068 ）

ISSN： 1570-0232

年卷期： 2010 年 878 卷 31 期

页码：

收录情况： SCI

摘要： A hydrophilic interaction high-performance liquid chromatography coupled with tandem mass spectrometry method for determination of N-methyl-2-pyrrolidinone in swine liver was developed and validated After the fortification of N-methyl-d(3)-2-pyrrolidinone-d(6) as the deuterium-labeled Internal standard N-methyl-2-pyrrolidinone in swine liver was extracted by acetonitrile and the supernatant was led through a C18 + WAX mixed-mode SPE cartridge for removal of the matrix interferences The final eluate was acidified by formic acid and then injected onto a 3 mu m 15 cm x 2 1 mm TX column for hydrophilic interaction chromatographic analysis Mass spectrometry detection was carried on a PE Sciex API 4000 triple quadrupole mass spectrometer using positive turbo-ion spray ionization mode The MRM transitions were 100 -> 58 for N-methyl-2-pyrrolidinone and 109 -> 62 for N-methyl-d(3)-2-pyrrolidinone-d(6) Solvent calibration standards could be readily used for quantitative analysis of N-methyl-2-pyrrolidinone with excellent precision and accuracy although there are endogenous levels of N-methyl-2-pyrrolidinone in many blank matrices The true recovery was nearly 100% and the MRM signal of N-methyl-2-pyrrolidinone was suppressed about 30% because of the matrix effect Nevertheless N-methyl-d(3)-2-pyrrolidinone-d(6) completely compensated the ion-suppression effect and the injection-to-injection variation The detection limit was 5 ng g(-1) swine liver The validated method was applied to a depletion study of N-methyl-2-pyrrolidinone in swine liver following intramuscular administration of a drug N-methyl-2-pyrrolidinone formulation (C) 2010 Elsevier B V All rights reserved

分类号：

  • 相关文献

[1]Rapid and accurate determination of dichlorvos in water by liquid chromatography-electrospray ionization-tandem mass spectrometry. Yang, Lan,Liu, Yan Hong,An, Li Zhe,Li, You-bin.

[2]Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma. Yang, Yuhui,Zhang, Weihua,Liu, Yanhong.

[3]Validated hydrophilic interaction LC-MS/MS method for determination of 2-pyrrolidinone residue: Applied to a depletion study of 2-pyrrolidinone in swine liver. Liu, Yanhong,Chen, Ximing,Ji, Yanhong,Chen, Jiangtao,Wang, Guangxiang,Shang, Youjun,Liu, Xiangtao,Pan, Jack.

[4]The Determination of PAHs in Fish by GC-QqQ-MS/MS. Li, Hui-Dong,Wang, Wen-Bo,Chen, Zi-Lei,Ding Ruiyan,Fang Liping,Wang Fengen,Lu, Xiao,Huo, Lu-Ge,Yang, Guo-Sheng,Li, Hui-Dong,Wang, Wen-Bo,Chen, Zi-Lei,Ding Ruiyan,Fang Liping,Wang Fengen,Lu, Xiao,Li, Hui-Dong,Wang, Wen-Bo,Chen, Zi-Lei,Ding Ruiyan,Fang Liping,Wang Fengen,Lu, Xiao,Aboul-Enein, Hassan Y.. 2013

[5]Simultaneous determination of 13 phytohormones in oilseed rape tissues by liquid chromatography-electrospray tandem mass spectrometry and the evaluation of the matrix effect. Fan, Sufang,Wang, Xiupin,Li, Peiwu,Zhang, Qi,Zhang, Wen,Fan, Sufang,Wang, Xiupin,Li, Peiwu,Zhang, Qi,Zhang, Wen,Fan, Sufang,Wang, Xiupin,Li, Peiwu.

[6]Phage-Displayed Peptide That Mimics Aflatoxins and Its Application in Immunoassay. Wang, Yanru,Zhang, Qi,Wang, Yanru,Li, Peiwu,Wang, Yanru,Li, Peiwu,Zhang, Qi,Wang, Yanru,Li, Peiwu,Wang, Hong,Kim, Hee Jou,Gee, Shirley J.,Hammock, Bruce D.,Wang, Hong,Kim, Hee Jou,Gee, Shirley J.,Hammock, Bruce D..

[7]Determination of Multi-Class Mycotoxins in Tartary Buckwheat by Ultra-Fast Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry. Ren, Guixing,Hu, Yichen,Zou, Liang,Zhao, Gang,Ren, Guixing,Zhang, Jinming. 2018

[8]Simultaneous determination of aflatoxin M-1, ochratoxin A, zearalenone and alpha-zearalenol in milk by UHPLC-MS/MS. Huang, L. C.,Zheng, N.,Wen, F.,Cheng, J. B.,Han, R. W.,Xu, X. M.,Li, S. L.,Wang, J. Q.,Huang, L. C.,Cheng, J. B.,Zheng, B. Q.,Huang, L. C.,Zheng, N.,Wen, F.,Han, R. W.,Xu, X. M.,Li, S. L.,Wang, J. Q.,Wang, J. Q.. 2014

[9]Detection of ractopamine residues in pork by surface plasmon resonance-based biosensor inhibition immunoassay. Zheng, Hong,Yang, Guo-Sheng,Lu, Xiao,Li, Xiu-Qing,Yuan, Xue-Xia,Deng, Li-Gang,Zhang, Hong,Wang, Wen-Zheng,Lu, Xiao,Li, Xiu-Qing,Yuan, Xue-Xia,Deng, Li-Gang,Zhang, Hong,Wang, Wen-Zheng,Yang, Guo-Sheng,Li, Hui,Meng, Meng,Xi, Ri-Mo,Aboul-Enein, Hassan Y..

[10]A sensitive chemiluminescence enzyme immunoassay based on molecularly imprinted polymers solid-phase extraction of parathion. Chen, Ge,Jin, Maojun,Du, Pengfei,Zhang, Chan,Cui, Xueyan,Zhang, Yudan,She, Yongxin,Shao, Hua,Jin, Fen,Wang, Shanshan,Zheng, Lufei,Wang, Jing.

[11]Comparative proteomic analyses of two Taxus species (Taxus X media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites. Juan Hao,Shen, Chenjia,Hong Guo,Xinai Shi,Ye Wang,Qinghua Wan,Yao-Bin Song,Lei Zhang,Ming Dong,Chenjia Shen. 2017

[12]Validated LC-MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study. Zhai, Qianqian,Pang, Jing,Li, Guoqing,Li, Congran,Yang, Xinyi,Yu, Liyan,Wang, Yucheng,You, Xuefu,Zhai, Qianqian,Pang, Jing,Li, Guoqing,Li, Congran,Yang, Xinyi,Yu, Liyan,Wang, Yucheng,You, Xuefu,Zhai, Qianqian,Li, Jian. 2015

[13]A method for multiple identification of four beta(2)-Agonists in goat muscle and beef muscle meats using LC-MS/MS based on deproteinization by adjusting pH and SPE for sample cleanup. Xiong, Lin,Gao, Ya-Qin,Li, Wei-Hong,Guo, Tian-Feng,Yang, Xiao-Lin,Xiong, Lin,Gao, Ya-Qin,Li, Wei-Hong,Guo, Tian-Feng,Yang, Xiao-Lin. 2015

[14]Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method Coupled with Dispersive Solid-Phase Extraction for Simultaneous Quantification of Eight Paralytic Shellfish Poisoning Toxins in Shellfish. Yang, Xianli,Zhao, Zhiyong,Nie, Dongxia,Zhou, Changyan,Zhou, Lei,Shi, Xizhi,Tan, Yanglan,Liu, Hong. 2017

[15]Serum Metabolic Profiling of Oocyst-Induced Toxoplasma gondii Acute and Chronic Infections in Mice Using Mass-Spectrometry. Zhou, Chun-Xue,Chen, Xiao-Qing,Zhu, Xing-Quan,Zhou, Chun-Xue,He, Shen-Yi,Cong, Wei,Chen, Xiao-Qing,Elsheikha, Hany M.. 2018

[16]Simultaneous analysis of cyromazine, sulfonamides and tetracyclines in animal wastewater and soil samples by optimized LC-MS/MS. Wei, Ruicheng. 2012

[17]Investigation of metabolites accumulation in medical plant Gentiana rigescens during different growing stage using LC-MS/MS and FT-IR. Pan, Yu,Zhang, Ji,Zhao, Yan-Li,Wang, Yuan-Zhong,Pan, Yu,Huang, Heng-Yu. 2015

[18]Stereoselective dissipation of epoxiconazole in grape (Vitis vinifera cv. Kyoho) and soil under field conditions. Liang, Hongwu,Li, Li,Li, Wei,Qiu, Jing,Liang, Hongwu,Zhou, Zhiqiang,Liu, Fengmao,Qiu, Lihong.

[19]Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers. Yang, Yajun,Li, Jianyong,Liu, Yurong,Zhang, Jiyu,Li, Bing,Cai, Xuepeng.

[20]Liquid Chromatography Tandem Mass Spectrometry Combined with Fourier Transform Mid-Infrared Spectroscopy and Chemometrics for Comparative Analysis of Raw and Processed Gentiana rigescens. Pan, Yu,Zhang, Ji,Zhao, Yan-Li,Zuo, Zhi-Tian,Wang, Yuan-Zhong,Li, Wan-Yi,Pan, Yu,Li, Wan-Yi,Shen, Tao.

作者其他论文 更多>>

微信小程序