AtCHE1, the Arabidopsis homolog of mammalian AATF/Che-1 protein, is involved in safeguarding genome stability

文献类型： 外文期刊

第一作者： Liu, Fang

作者： Liu, Fang;Wang, Xiangyang;Qi, Shengdong;Li, Xugang;Liu, Fang;Wang, Bingshan;Palme, Klaus;Wang, Xiangyang;Dong, Daofeng;De Veylder, Lieven;De Veylder, Lieven;Horvath, Beatrix M.;Horvath, Beatrix M.;Palme, Klaus;Li, Xugang;Palme, Klaus

作者机构：

期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：5.1； 五年影响因子：5.8 ）

ISSN：

年卷期： 2025 年 8 卷 1 期

页码：

收录情况： SCI

摘要： Both endogenous and exogenous genotoxins can inflict damage on cellular DNA, leading to reduced genomic stability in plants, which adversely affects development. Apoptosis Antagonizing Transcription Factor (AATF), also referred to as Che-1, has been identified as a binding protein for RNA polymerase II. It plays a crucial role in various cellular processes, including cell proliferation, transcriptional regulation, apoptosis, DNA damage response, and ribosome biogenesis in mammals. In this study, we identify the che1 mutant derived from an ethyl methanesulfonate (EMS)-mutagenized Arabidopsis Col-0 population, characterized by a short root and small leaf phenotype. The underlying mutation is a G-to-A transition located at the boundary of the eighth intron and ninth exon of the AT5G61330 gene, resulting in a misprocessed mRNA transcript. AtCHE1, a homolog of the mammalian AATF/Che-1, contains both the conserved AATF/Che-1 and TRAUB domains in Arabidopsis. Under standard conditions, the che1 mutant exhibits an accumulation of damaged DNA, cell death, and differentiation defects at the root tip. Collectively, these findings underscore the importance of AtChe-1 in meristem maintenance and genome stability.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序