Roles of CD122(+) Cells in Resistance against Neospora caninum Infection in a Murine Model

文献类型： 外文期刊

第一作者： Nishikawa, Yoshifumi

作者： Nishikawa, Yoshifumi;Zhang, Houshuang;Ibrahim, Hany M.;Yamada, Kyoko;Nagasawa, Hideyuki;Xuan, Xuenan;Zhang, Houshuang;Ibrahim, Hany M.

作者机构：

关键词： immune system;Neospora caninum;parasite

期刊名称：JOURNAL OF VETERINARY MEDICAL SCIENCE （ 影响因子：1.267； 五年影响因子：1.348 ）

ISSN： 0916-7250

年卷期： 2010 年 72 卷 10 期

页码：

收录情况： SCI

摘要： Innate cells, such as natural killer (NK) cells and NKT cells, play essential roles as primary effector cells at the interface between the host and parasite until establishment of adaptive immunity. However, the roles of NK and NKT cells in defense against Neospora Caninum have not been well clarified. NK and NKT cells were depleted by the treatment with an anti-CD122 (interleukin-2 receptor beta chain) monoclonal antibody (mAb, TM-beta 1) in vivo. The parasite burden in the brain of mice was promoted by the treatment with anti-CD122 mAb. However, there was no significant difference in the infection rates between controls and the mice treated with anti-asialoGM1 antibody to deplete NK cells. Activation of CD4(+) T cells was suppressed in the mice treated with anti-CD122 mAb compared with controls and the mice treated with anti-asialoGM1 antibody. On the other hand, depletion of CD122(+) cells or NK cells did not affect the number of activated CD8(+) T cells, dendritic cells and B cells following N. caninum infection. These results indicate that CD122(+) cells (probably NKT cells) play a crucial role in host defense by activating CD4(+) T cells against N. caninum infection.

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