Epigenetic regulation of adipocyte differentiation and adipogenesis

文献类型: 外文期刊

第一作者: Li, Hong-xing

作者: Li, Hong-xing;Xiao, Lei;Gao, Jia-li;Zhai, Yong-gong;Xiao, Lei;Gao, Jia-li;Zhai, Yong-gong;Xiao, Lei;Gao, Jia-li;Zhai, Yong-gong;Xiao, Lei;Gao, Jia-li;Zhai, Yong-gong;Wang, Cheng

作者机构:

关键词: Epigenetic regulation;Histone modification;DNA methylation;Differentiation;Adipogenesis

期刊名称:JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B ( 影响因子:3.066; 五年影响因子:3.057 )

ISSN: 1673-1581

年卷期: 2010 年 11 卷 10 期

页码:

收录情况: SCI

摘要: It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.

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