Memory Impairment in Cognitively Impaired Aged Rats Associated With Decreased Hippocampal CREB Phosphorylation: Reversal by Procyanidins Extracted From the Lotus Seedpod

文献类型: 外文期刊

第一作者: Xu, Jiqu

作者: Xu, Jiqu;Rong, Shuang;Wu, Hailei;Bao, Wei;Wang, Di;Yao, Ping;Liu, Liegang;Xu, Jiqu;Deng, Qianchun;Huang, Fenghong;Rong, Shuang;Wu, Hailei;Bao, Wei;Wang, Di;Yao, Ping;Liu, Liegang;Xie, Bijun;Sun, Zhida

作者机构:

关键词: Procyanidins;Memory;CREB;BDNF;ERK;Hippocampus

期刊名称:JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES ( 影响因子:6.053; 五年影响因子:6.356 )

ISSN: 1079-5006

年卷期: 2010 年 65 卷 9 期

页码:

收录情况: SCI

摘要: The major purpose of this study was to determine the effects of procyanidins extracted from the lotus seedpod on cAMP-response element-binding protein phosphorylation in hippocampus and cerebral cortex in cognitively impaired aged rats. Based on Morris water maze, aged unimpaired and aged impaired rats were chosen from aged rats. Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. These results suggested that lotus seedpod might enhance cAMP-response element-binding-dependent transcription through the activation of extracellular signal-related kinase signalling pathway, which might contribute to its ameliorative effects on cognitive deficits in aged impaired animals.

分类号:

  • 相关文献

[1]MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF. Wang, Peisong,Meng, Xianying,Liu, Jia,Wang, Guimin,Meng, Wei,Xue, Shuai,Zhang, Qiang,Chen, Guang,Huang, Yan,Lv, Zhi,Zhang, Pengju. 2017

[2]Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model. Yin, Xiang,Jiang, Haizhi,Wang, Shuyu,Jiang, Hongquan,Qi, Yan,Wang, Jing,Wang, Xudong,Dong, Guangtao,Feng, Honglin,Ren, Ming,Cui, Shangjin,Leeds, Peter,Chuang, De-Maw.

[3]Activation of cAMP-response element-binding protein is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC in insect. Yang, Huipeng,He, Xiaobai,Deng, Xiaoyan,Liao, Yuan,Zhu, Chenggang,Shi, Ying,Zhou, Naiming,Yang, Jingwen,Zhang, Zhifang.

[4]Effects of duloxetine on microRNA expression profile in frontal lobe and hippocampus in a mouse model of depression. Pan, Bing,Liu, Yamei. 2015

[5]Microcystin-LR inhibited hippocampal long-term potential via regulation of the glycogen synthase kinase-3 beta pathway. Wang, Jianghua,Zhou, Qiong,Lin, Fankai,Cai, Fei,Yan, Wei,Xie, Liqiang. 2013

[6]The teleost humoral immune response. Ye, Jianmin,Kaattari, Ilsa M.,Kaattari, Stephen,Ma, Cuiyan. 2013

[7]ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway. Liu, Jia,Ma, Leina,Chen, Xiao,Wang, Jianxun,Yu, Tao,Gong, Ying,Ma, Aiguo,Liang, Hui,Ma, Leina,Zheng, Lanhong. 2016

[8]TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells. Lu, Ziyin,Xie, Daoyuan,Chen, Ying,Tian, Erjie,Muhammad, Ishfaq,Chen, Xueping,Miao, Yusong,Hu, Wanjun,Wu, Ziyong,Ni, Huili,Li, Jichang,Xin, Jiuqing,Li, Yuan.

[9]In vitro antioxidant activities of proanthocyanidins extracted from the lotus seedpod and ameliorative effects on learning and memory impairment in scopolamine-induced amnesia mice. Sui, Yong,Li, Xiaopeng,Wu, Qian,Xie, Bijun,Sun, Zhida,Xiao, Juan,Zhang, Ruifen,Zhang, Mingwei,Li, Shuyi. 2015

[10]The toxic influence of paraquat on hippocampal neurogenesis in adult mice. Li, Kaikai,Cheng, Xinran,Wang, Jiutao,Xie, Jiongfang,Hu, Xinde,Huang, Yingxue,Song, Lingzhen,Liu, Mengmeng,Zhao, Shanting,Jiang, Jinhua,Cai, Leiming,Chen, Liezhong,Wang, Jiutao.

[11]Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. Wang, Jing,Lv, Xiao-Wen,Shi, Jie-Ping,Hu, Xiao-Song. 2007

[12]Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death. Zhou, Jian-Hua,Yu, David V.,Cheng, Jingwei,Shapiro, David J.. 2007

[13]Optimized ultra-high-pressure-assisted extraction of procyanidins from lychee pericarp improves the antioxidant activity of extracts. Zhang, Ruifen,Zhang, Mingwei,Su, Dongxiao,Zhang, Ruifen,Liu, Lei,Huang, Fei,Dong, Lihong,Deng, Yuanyuan,Zhang, Yan,Wei, Zhencheng,Zhang, Mingwei,Hou, Fangli. 2017

[14]Phenolic Profiles and Antioxidant Activity of Litchi (Litchi Chinensis Sonn.) Fruit Pericarp from Different Commercially Available Cultivars. Li, Wu,Liang, Hong,Zhang, Ming-Wei,Zhang, Rui-Fen,Deng, Yuan-Yuan,Wei, Zhen-Cheng,Zhang, Yan,Tang, Xiao-Jun. 2012

[15]Analysis of distribution and pharmacokinetics of litchi pericarp procyanidins in rat plasma and organs by using liquid chromatography-tandem mass spectrometry. Wu, Qian,Li, Shuyi,Sui, Yong,Xie, Bijun,Sun, Zhida,Xiao, Juan.

作者其他论文 更多>>