Memory Impairment in Cognitively Impaired Aged Rats Associated With Decreased Hippocampal CREB Phosphorylation: Reversal by Procyanidins Extracted From the Lotus Seedpod
文献类型: 外文期刊
第一作者: Xu, Jiqu
作者: Xu, Jiqu;Rong, Shuang;Wu, Hailei;Bao, Wei;Wang, Di;Yao, Ping;Liu, Liegang;Xu, Jiqu;Deng, Qianchun;Huang, Fenghong;Rong, Shuang;Wu, Hailei;Bao, Wei;Wang, Di;Yao, Ping;Liu, Liegang;Xie, Bijun;Sun, Zhida
作者机构:
关键词: Procyanidins;Memory;CREB;BDNF;ERK;Hippocampus
期刊名称:JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES ( 影响因子:6.053; 五年影响因子:6.356 )
ISSN: 1079-5006
年卷期: 2010 年 65 卷 9 期
页码:
收录情况: SCI
摘要: The major purpose of this study was to determine the effects of procyanidins extracted from the lotus seedpod on cAMP-response element-binding protein phosphorylation in hippocampus and cerebral cortex in cognitively impaired aged rats. Based on Morris water maze, aged unimpaired and aged impaired rats were chosen from aged rats. Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. These results suggested that lotus seedpod might enhance cAMP-response element-binding-dependent transcription through the activation of extracellular signal-related kinase signalling pathway, which might contribute to its ameliorative effects on cognitive deficits in aged impaired animals.
分类号:
- 相关文献
作者其他论文 更多>>
-
Flaxseed protein isolates-stabilized oil-water interface: Role of globulin and albumin
作者:Yang, Jing;Shao, Jiaqi;Peng, Dengfeng;Deng, Qianchun;Yang, Jing;Shao, Jiaqi;Peng, Dengfeng;Deng, Qianchun;Yang, Jing;Li, Dapeng;Duan, Yuqing;Zhang, Haihui;Ashokkumar, Muthupandian
关键词:Flaxseed protein fractions; Structure properties; Interfacial behavior; Oil-water interface
-
Exploring the key flavor compounds and aroma profiles in traditionally fermented golden pompano (Trachinotus ovatus): Perspective from molecular sensory science
作者:Li, Yujie;Wu, Yanyan;Chen, Shengjun;Zhao, Yongqiang;Li, Chunsheng;Xiang, Huan;Wang, Di;Wang, Yueqi;Li, Yujie;Wu, Yanyan;Chen, Shengjun;Zhao, Yongqiang;Li, Chunsheng;Wang, Yueqi;Li, Yujie
关键词:Fermented golden pompano; Molecular sensory science; Gas chromatography-olfactometry-mass spectrometry; Aroma dilution analysis; Aroma recombination; Omission experiments; Omission experiments
-
Comparative transcriptome profiling reveals the key genes and molecular mechanisms involved in rice under blast infection
作者:Li, Gang;Wang, Jian;Cheng, Baoshan;Wang, Di;Gao, Hao;Xu, Weijun;Wang, Wei;Gao, Qingsong;Zhang, Wenxia;Ji, Jianhui;Li, Bianhao;Zhang, Guoliang;Qi, Zhongqiang;Liu, Yongfeng
关键词:Rice; Blast; Transcriptome; Disease resistance; Hormones; Biochemical indicators
-
Structural characterization and hypolipidemic activity of a hetero-galactan purified from Sanghuangporus vaninii based on modulation of TLR4/NF-κB pathway
作者:Hao, Jie;Zhu, Yanfeng;Li, Zhige;Wang, Lu;Qu, Yidi;Wang, Di;Zhang, Yongfeng;Li, Lanzhou;Wang, Di;Yu, Hailong;Qi, Liangliang
关键词:Sanghuangporus vaninii; Polysaccharide; Hypolipidemic efficacy; Inflammation; TLR4/NF-kappa B
-
Unlocking the chemical basis of fermented golden pompano (Trachinotus ovatus) inoculated with indigenous Bacillus subtilis: Focus on the role of lipid oxidation on volatile flavor formation
作者:Wang, Huifang;Wu, Yanyan;Chen, Shengjun;Zhao, Yongqiang;Li, Chunsheng;Xiang, Huan;Wang, Di;Wei, Ya;Wang, Yueqi;Wu, Yanyan;Chen, Shengjun;Zhao, Yongqiang;Wang, Yueqi;Wang, Huifang
关键词:Fermented golden pompano; Bacillus subtilis; Inoculation fermentation; Volatile compound; Lipid oxidation; Metabolic pathway
-
Comparative transcriptomics and metabolomics provide insight into degeneration-related physiological mechanisms of Morchella importuna after long-term preservation
作者:Chen, Ying;Cao, Xuelian;Xie, Liyuan;Tang, Jie;Liu, Lixu;Wang, Di;Wu, Xiang;Liu, Tianhai;Yu, Yang;Wang, Yong;Peng, Weihong;Tan, Hao;Martin, Francis;Tan, Hao;Martin, Francis
关键词:
-
Pharmacokinetics, Withdrawal Time, and Physiological Effects of Single Oral Administration of Enrofloxacin in Dybowski's Frog (Rana dybowskii)
作者:Wang, Yanan;Wang, Jing;Zhao, Ran;Li, Shaowu;Hu, Guo;Wang, Di;Wang, Yanan
关键词:
Rana dybowskii ; enrofloxacin; ciprofloxacin; pharmacokinetic; withdrawal time