Neospora caninum: Application of apical membrane antigen 1 encapsulated in the oligomannose-coated liposomes for reduction of offspring mortality from infection in BALB/c mice

文献类型： 外文期刊

第一作者： Zhang, Houshuang

作者： Zhang, Houshuang;Nishikawa, Yoshifumi;Yamagishi, Junya;Yokoyama, Naoaki;Xuan, Xuenan;Zhang, Houshuang;Zhou, Jinlin;Ikehara, Yuzuru;Kojima, Naoya

作者机构：

关键词： Neospora caninum;Apical membrane antigen 1;Oligomannose-coated liposomes

期刊名称：EXPERIMENTAL PARASITOLOGY （ 影响因子：2.011； 五年影响因子：2.132 ）

ISSN： 0014-4894

年卷期： 2010 年 125 卷 2 期

页码：

收录情况： SCI

摘要： Liposomes coated with neoglycolipids constructed with mannopentaose and dipalmitoylphosphatidy-lethanolamine (M3-DPPE), referred to as M3-DPPE liposomes, have been shown to induce cellular immunity against antigens encapsulated therein. To evaluate whether these M3-DPPE liposomes have an adjuvant capacity against Neospora caninum infection, a novel immunization method utilizing soluble N. caninum apical membrane antigen 1 (NcAMA1) encapsulated in the M3-DPPE liposomes (M3-NcAMA1) was employed. The results revealed that a significant amount of interferon (IFN)-gamma production was detected in culture supernatants of NcAMA1 protein- or N. caninum lysate-stimulated spleen cells obtained from the mice one week after the third immunization with M3-NcAMA1. The parasite burden in the dams' brain tissue was decreased and the survival rate of offspring increased significantly in M3-NcAMA1-immunized mice. Thus, a parasite-specific Th1 immune response was successfully induced in the pregnant mice immunized with M3-NcAMA1, and an effective reduction of offspring mortality from N. caninum infection was triggered. (C) 2010 Elsevier Inc. All rights reserved.

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