文献类型： 外文期刊
第一作者： Li, Yingrui
作者： Li, Yingrui;Chen, Ze;Guo, Jia;Meng, Deshuang;Pang, Xin;Sun, Zepeng;Pu, Li;Yang, Shuiyue;Yang, Min;Peng, Yinghua;Pang, Xin;Sun, Zepeng;Pu, Li;Yang, Shuiyue;Peng, Yinghua
作者机构：
关键词： Cannabidiol; Exosomes; Brain-targeted delivery; Drug delivery; RVG
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：2.5； 五年影响因子：2.7 ）
ISSN： 0006-291X
年卷期： 2024 年 725 卷
页码：
收录情况： SCI
摘要： This study introduces an innovative brain-targeted drug delivery system, RVG-Exo/CBD, utilizing rabies virus glycoprotein (RVG)-engineered exosomes for encapsulating cannabidiol (CBD). The novel delivery system was meticulously characterized, confirming the maintenance of exosomal integrity, size, and successful drug encapsulation with a high drug loading rate of 83.0 %. Evaluation of the RVG-Exo/CBD's brain-targeting capability demonstrated superior distribution and retention in brain tissue compared to unmodified exosomes, primarily validated through in vivo fluorescence imaging. The efficacy of this delivery system was assessed using a behavioral sensitization model in mice, where RVG-Exo/CBD notably suppressed methamphetamine-induced hyperactivity more effectively than CBD alone, indicating a reduction in effective dose and enhanced bioavailability. Overall, the RVG-Exo/CBD system emerges as a promising strategy for enhancing the therapeutic efficacy and safety of CBD, particularly for neurological applications, highlighting its potential for addressing the limitations associated with traditional CBD administration in clinical settings.
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