Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system

文献类型： 外文期刊

第一作者： Li, Yingrui

作者： Li, Yingrui;Chen, Ze;Guo, Jia;Meng, Deshuang;Pang, Xin;Sun, Zepeng;Pu, Li;Yang, Shuiyue;Yang, Min;Peng, Yinghua;Pang, Xin;Sun, Zepeng;Pu, Li;Yang, Shuiyue;Peng, Yinghua

作者机构：

关键词： Cannabidiol; Exosomes; Brain-targeted delivery; Drug delivery; RVG

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：2.5； 五年影响因子：2.7 ）

ISSN： 0006-291X

年卷期： 2024 年 725 卷

页码：

收录情况： SCI

摘要： This study introduces an innovative brain-targeted drug delivery system, RVG-Exo/CBD, utilizing rabies virus glycoprotein (RVG)-engineered exosomes for encapsulating cannabidiol (CBD). The novel delivery system was meticulously characterized, confirming the maintenance of exosomal integrity, size, and successful drug encapsulation with a high drug loading rate of 83.0 %. Evaluation of the RVG-Exo/CBD's brain-targeting capability demonstrated superior distribution and retention in brain tissue compared to unmodified exosomes, primarily validated through in vivo fluorescence imaging. The efficacy of this delivery system was assessed using a behavioral sensitization model in mice, where RVG-Exo/CBD notably suppressed methamphetamine-induced hyperactivity more effectively than CBD alone, indicating a reduction in effective dose and enhanced bioavailability. Overall, the RVG-Exo/CBD system emerges as a promising strategy for enhancing the therapeutic efficacy and safety of CBD, particularly for neurological applications, highlighting its potential for addressing the limitations associated with traditional CBD administration in clinical settings.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序