Chicken Polymorphism at Pre-MicroRNAs Inferred from SNP Data

文献类型： 外文期刊

第一作者： Zhang, Chuan-sheng

作者： Zhang, Chuan-sheng;Geng, Li-ying;Zhang, Jin;Zhu, Wen-jin;Du, Li-xin

作者机构：

关键词： chicken;pre-microRNA;Bioinformatic;SNP

期刊名称：2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010)

ISSN： 2151-7614

年卷期： 2010 年

页码：

收录情况： SCI

摘要： In this study, the SNPs located in the chicken premicroRNAs were performed a genome-wide analysis. The result showed that pre-microRNA SNPs are negatively selected in respect to SNPs distribution between the pre-microRNA and their flanking regions. Interestingly, the seed regions show a higher SNP density than both the MIR and the other MIR regions excluding seed regions. Furthermore, the SNPs in the seed regions were found show fewer effects on the stability of the pre-microRNA secondary structure. The data suggest that there is a rapid evolution has occurred in the seed regions and these SNPs are tend to be more deleterious, being good candidates for causal phenotypic variability among chickens. These findings will improve our understanding of the functions, evolution of chicken pre-microRNAs.

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