IL-18 enhances protective effect in mice immunized with a Schistosoma japonicum FABP DNA vaccine

文献类型： 外文期刊

第一作者： Wei, Feng

作者： Wei, Feng;Liu, Quan;Zhai, Yujia;Liu, Wensen;Shang, Limin;Men, Jingtao;Gao, Shengyan;Lian, Hai;Jin, Hongtao;Chen, Chen;Xia, Zhiping;Fu, Zhiqiang;Lin, Jiaojiao;Shi, Yaojun;Zhu, Xing-Quan;Wei, Feng

作者机构：

关键词： Schistosoma japonicum;SjFABP;IL-18;DNA vaccine;Mice

期刊名称：ACTA TROPICA （ 影响因子：3.112； 五年影响因子：3.002 ）

ISSN： 0001-706X

年卷期： 2009 年 111 卷 3 期

页码：

收录情况： SCI

摘要： Two recombinant plasmids, pVAX/SjFABP and pVAX/mIL-18 containing Schistosoma japonicum 14 kDa fatty acid binding protein (SjFABP) and murine IL-18, were constructed and evaluated for their ability to induce immune responses and to protect against S. japonicum challenge in mice. Mice were intramuscularly immunized twice at three-weekly intervals, and challenged with S. japonicum cercariae at 4 weeks after the last vaccination. All animals vaccinated with pVAX/SjFABP alone or plus pVAX/mIL-18 developed specific anti-SWAP ELISA antibody and T lymphocyte proliferation. Co-injection of pVAX/mIL-18 significantly increased the production of IFN-gamma and IL-2 compared with pVAX/SjFABP alone, indicating that IL-18 enhances the Th1-dominant immune response. The challenge experiment showed that co-injection of plasmid encoding IL-18 significantly enhances protective effect against S. japonicum infection, as demonstrated by worm reduction rates and the hepatic egg reduction rates 45 days post-challenge. These results indicated that IL-18 may become a novel vaccine adjuvant for development of vaccines against schistosomiasis. (C) 2009 Elsevier B.V. All rights reserved.

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