DNA-Bound peptides control the mRNA transcription through CDK7

文献类型： 外文期刊

第一作者： Lv, Xiaowen

作者： Lv, Xiaowen;Lv, Feijie;Qin, Yuchang;Wang, Jing;Dong, Zhiyuan

作者机构：

关键词： DNA-Bound peptides;Proteasome;Cyclin-dependent kinase-7;Transcription

期刊名称：PEPTIDES （ 影响因子：3.75； 五年影响因子：3.389 ）

ISSN： 0196-9781

年卷期： 2009 年 30 卷 4 期

页码：

收录情况： SCI

摘要： The degradation of intracytosolic proteins has been well described. However, the degradation pathway and physiological functions of the DNA-Bound peptides, which are free of degradation by peptidase of the post-ubiquitin-proteasome pathway, are still unclear. In this study, the DNA-Bound peptides were isolated from barley germ and two main fractions of about 25 different peptides were obtained. The DNA-Bound peptides were found to inhibit the proliferation of HeLa cells in a series of experiments. The DNA-Bound peptides also significantly inhibited in vitro and in vivo DNA transcription activity by regulating the expression and the corresponding functions of CDK7. Furthermore, signaling issues involving NF kappa B and ERK1/2 were observed. Such data suggests that DNA transcription could be inhibited by the DNA-Bound peptides via the CDK7 pathway. Thus we concluded that some of the post-proteasomal peptides were involved in the regulation of eukaryotic mRNA transcription. (c) 2008 Elsevier Inc. All rights reserved.

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