Genetic variation in the long terminal repeat associated with the transition of Chinese equine infectious anemia virus from virulence to avirulence

文献类型: 外文期刊

第一作者: Wei, Lili

作者: Wei, Lili;Lu, Xiaoling;Zhao, Liping;Xiang, Wenhua;Xue, Fei;Shen, Rongxian;Wang, Xiaojun;Wei, Lili;Fan, Xiujuan;Zhang, Xiaoyan;Shao, Yiming

作者机构:

关键词: EIAV;LTR;Mutation;Attenuation

期刊名称:VIRUS GENES ( 影响因子:2.332; 五年影响因子:2.0 )

ISSN: 0920-8569

年卷期: 2009 年 38 卷 2 期

页码:

收录情况: SCI

摘要: A highly virulent strain of equine infectious anemia virus (EIAV) lost its fatal virulence but retained the desired antigens during serial passage over 130 generations in leukocytes in vitro. We compared the long terminal repeat (LTR) sequences of the different generations and found that three stable genetic variations occurred in the transcriptional start site, the initial base of TAR, and the pre-mRNA cleavage site at the R-U5 boundary, respectively. These three mutations happened at the inflexion of virus pathogenicity loss; therefore, the function of these mutations needs to be further addressed.

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