Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity

文献类型: 外文期刊

第一作者: Liu, Xing-Hai

作者: Liu, Xing-Hai;Ma, Yi;Dong, Wei-Li;Zhang, Chuan-Yu;Wang, Bao-Lei;Wang, Su-Hua;Li, Zheng-Ming;Shi, Yan-Xia;Li, Bao-Ju;He, Guo-Rong;He, Guo-Rong

作者机构:

关键词: 1;1-diphenyl-2-picrylhydrazyl radical-scavenging activity;antifungal activities;comparative molecular field analysis;diacylhydrazines

期刊名称:CHEMICAL BIOLOGY & DRUG DESIGN ( 影响因子:2.817; 五年影响因子:2.631 )

ISSN: 1747-0277

年卷期: 2009 年 73 卷 3 期

页码:

收录情况: SCI

摘要: A series of N,N'-diacylhydrazines were prepared and their structures were confirmed by (1)H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure-activity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.

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