Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity
文献类型: 外文期刊
第一作者: Liu, Xing-Hai
作者: Liu, Xing-Hai;Ma, Yi;Dong, Wei-Li;Zhang, Chuan-Yu;Wang, Bao-Lei;Wang, Su-Hua;Li, Zheng-Ming;Shi, Yan-Xia;Li, Bao-Ju;He, Guo-Rong;He, Guo-Rong
作者机构:
关键词: 1;1-diphenyl-2-picrylhydrazyl radical-scavenging activity;antifungal activities;comparative molecular field analysis;diacylhydrazines
期刊名称:CHEMICAL BIOLOGY & DRUG DESIGN ( 影响因子:2.817; 五年影响因子:2.631 )
ISSN: 1747-0277
年卷期: 2009 年 73 卷 3 期
页码:
收录情况: SCI
摘要: A series of N,N'-diacylhydrazines were prepared and their structures were confirmed by (1)H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure-activity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.
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