Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia

文献类型： 外文期刊

第一作者： Hou, X. Q.

作者： Hou, X. Q.;Gao, Y. W.;Yang, S. T.;Wang, C. Y.;Xia, X. Z.;Hou, X. Q.;Ma, Z. Y.

作者机构：

关键词： MIF;H5N1 influenza virus;mice;pneumonia;isoxazolone-1

期刊名称：ACTA VIROLOGICA （ 影响因子：1.162； 五年影响因子：1.255 ）

ISSN： 0001-723X

年卷期： 2009 年 53 卷 4 期

页码：

收录情况： SCI

摘要： The severe and often fatal disease in humans and birds caused by H5N1 influenza viruses has been attributed to aberrant pulmonary inflammatory responses. We investigated the role of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and a pivotal regulator of innate immunity, in H5N1 influenza virus pneumonia in murine model. We found increased MIF mRNA levels in the lungs and MIF protein levels in the serum of infected mice. Although the inhibition of MIF action by isoxazolone-1 (ISO-1) did not render mice more resistant to the lethality of infection, it caused a significant reduction in pulmonary inflammatory cytokines interleukin-1 beta (IL-1 beta), IL-6 and tumor necrosis factor alpha (TNF-alpha) and chemokine interferon-inducible protein-10 (IP-10). These results indicate the involvement of MIF in inflammatory responses to H5N1 influenza virus infections by induction of pulmonary inflammatory cytokines and chemokines, and suggest that pharmacotherapeutic approaches targeting MIF may hold promise for the treatment of H5N1 influenza virus pneumonia.

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