Lentiyirus-Mediated Knockdown of Cyclin Y (CCNY) Inhibits Glioma Cell Proliferation
文献类型: 外文期刊
第一作者: Xu, YongGang
作者: Xu, YongGang;Wang, Zhi;Li, JianHua;Wang, HongWei;Yue, Wu;Wang, Jie
作者机构:
关键词: Cyclin Y (CCNY);Glioma;RNAi
期刊名称:ONCOLOGY RESEARCH ( 影响因子:5.574; 五年影响因子:4.966 )
ISSN: 0965-0407
年卷期: 2009 年 18 卷 8 期
页码:
收录情况: SCI
摘要: Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (MAD of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation, colony formation, and cell cycle progression in glioma cells. These data suggest that CCNY might play an important role in glioma tumorigenisis.
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