Identification and Molecular Analysis of H5N2 Subtype Highly Pathogenic Avian Influenza Virus Isolated From Goose
文献类型: 外文期刊
第一作者: Liu Chun-Guo
作者: Liu Chun-Guo;Liu Ming;Liu Da-Fei;Du Jin-Ling;Li Hong-Tao;Liu Chun-Guo;Liu Ming;Liu Da-Fei;Du Jin-Ling;Li Hong-Tao;Zhang Yun;Pan Wei-Qi;Sun En-Cheng;Li Hong-Tao
作者机构:
关键词: goose;avian influenza virus;subtype H5N2;pathogenicity;sequence analysis
期刊名称:PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS ( 影响因子:0.351; 五年影响因子:0.272 )
ISSN: 1000-3282
年卷期: 2009 年 36 卷 1 期
页码:
收录情况: SCI
摘要: A H5N2 subtype avian influenza virus isolated from goose belongs to highly pathogenic avian influenza virus, and the intravenous pathogenicity indexes (IVPI) =2.99. But ducks are not sensitive to this isolated influenza virus. The virus can infect mouse but only replicates in lung and has no pathogenicity. HA and NA gene of this isolated strain share 99.4% and 99.8% nucleotide sequence identity to the HA gene of A/chicken/Hubei/ 489/2004 (H5N1) and the NA gene of A/chicken/Jilin/53/01 (H9N2), and share 99.3% and 99.6% amino acid sequence identity to the HA protein of A/chicken/Hubel/489/2004 (H5N1), A/swan/Guangxi/307/2004 (H5N1), A/wild duck/Guangdong/314/2004(H5N1), A/chicken/Henan/210/2004(H5N1) and the NA protein of A/chicken/ Jilin/53/01 (H9N2). There are several continuous basic amino acids (-RRRKKR-) at the cleavage site of HA protein. Phylogenetic trees analysis of HA and NA gene suggests that the isolated influenza virus probably originated from the reassortment of H5N1 and H9N2 subtype influenza virus.
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