Species differences for stereoselective metabolism of ethofumesate and its enantiomers in vitro
文献类型： 外文期刊
第一作者： Zhu, W.
作者： Zhu, W.;Dang, Z.;Liu, Y.;Lv, C.;Diao, J.;Zhou, Z.;Qiu, J.
作者机构：
关键词： Ethofumesate;liver microsomes;stereoselective metabolism;rabbit;rat
期刊名称：XENOBIOTICA （ 影响因子：1.908； 五年影响因子：1.917 ）
ISSN： 0049-8254
年卷期： 2009 年 39 卷 9 期
页码：
收录情况： SCI
摘要： 1. The stereoselective metabolism of ethofumesate (ETO) and its enantiomers in rabbit and rat liver microsomes have been studied by chiral high-performance liquid chromatography (HPLC) method. Two metabolites were detected in both liver microsomes in the presence of beta-nicotinamide adenine dinucleotide phosphate (NADPH). 2. The T-1/2 of (+)-ETO and (-)-ETO in rabbit liver microsomes were 12.2 and 4.7 min of rac-ETO and 25.9 and 6.7 of ETO enantiomers. However, the T-1/2 of (+)-ETO and (-)-ETO in rat liver microsomes were 5.3 and 5.9 min of rac-ETO and 7.8 and 10.6 of ETO enantiomers. The stereoselective selectivity is similar to the in vivo study. 3. After incubation of ETO enantiomers, stereoselectivity was present in the formation of ETO-OH enantiomer in rabbit liver microsomes, but stereoselectivity was not evident in rat liver microsomes. 4. There was no chiral inversion from the (+)-ETO to (-)-ETO or inversion from (-)-ETO to (+)-ETO in both rabbit and rat liver microsomes.
分类号：
- 相关文献
作者其他论文 更多>>
-
Supplementing pigeon grit with acidifier improves metabolism and the reproductive performance of breeding pigeons as well as the development of growth performance of squabs
作者：Zheng, S.;Tang, Y.;Huang, W.;Zhang, W.;Zhang, Y.;Yang, M.;Lu, H.;Li, Z.;He, Y.;Gao, H.;Wang, W.;Peng, J.;Huang, Y.;Liang, Y.;Qiu, X.;Liu, Y.;Gou, Z.;Qiu, Z.;Bin, Y.;Zhang, Z.;Wang, W.;Huang, Y.
关键词：Acidifier; breeder pigeon; squab; performance; metabolism
-
Genome-wide association study identifies multiple loci influencing duck serum biochemical indicators in the laying period
作者：Qi, J.;Li, J.;Liu, H.;Zhou, Z.;Jiang, Y.;Fan, W.;Hu, J.;Guo, Z.;Xie, M.;Huang, W.;Zhang, Q.;Hou, S.;Liu, H.;Zhou, Z.;Jiang, Y.;Fan, W.;Hu, J.;Guo, Z.;Xie, M.;Huang, W.;Zhang, Q.;Hou, S.;Liu, H.;Zhou, Z.;Jiang, Y.;Fan, W.;Hu, J.;Guo, Z.;Xie, M.;Huang, W.;Zhang, Q.;Hou, S.;Hou, S.
关键词：Serum; biochemical indicator; laying period; GWAS; ducks
-
Organic selenium supplementation increases serum selenium levels in healthy Xinjiang brown cattle fed selenised yeast
作者：Li, Z.;Tang, J.;Li, J.;Ling, D.;He, X.;Tang, Y.;Yi, P.;Yang, Y.;Li, Z.;Li, J.;He, X.;Tang, Y.;Yi, P.;Tang, J.;Khoo, H. E.;Liu, Y.
关键词：blood metabolites; Bos taurus; enzyme activity; red dates; slaughter performance
-
Comparative transcriptomic analyses reveal key genes underlying melanin distribution during embryonic development in geese (Anser anser)
作者：Yang, Y.;Wang, C.;Liu, Y.;Li, G.;Wang, X.;Wang, H.;He, D.
关键词：Graylag geese; melanin; genetics; dorsal skin; distal feet
-
Effects of fermented cottonseed meal inclusions on growth performance, serum biochemical parameters and hepatic lipid metabolism of geese during 28-70 d of age
作者：Xie, S. S.;Shen, J. J.;Liu, Y.;Wang, W. C.;Yang, L.;Zhu, Y. W.;Yang, Z. L.
关键词：goose; fermented cottonseed meal; growth performance; serum biochemical parameters; hepatic lipid metabolism
-
Transcriptome analysis reveals heat shock protein 70 (HSP70) induced by tembusu virus infection is associated with immune responses
作者：Zhao, D.;Han, K.;Zhang, L.;Huang, X.;Liu, Q.;Yang, J.;Liu, Y.;Li, Y.;Wu, F.;Zhao, D.;Zhao, D.;Zhao, D.;Han, K.;Zhang, L.;Huang, X.;Liu, Q.;Yang, J.;Liu, Y.;Li, Y.;Wu, F.
关键词：heat shock protein 70; innate immune response; tembusu virus; transcriptome analysis
-
Low-depth Raw Reads of Nanopore Sequencing Enables Rapid and Accurate Bacterial Identification
作者：Gao, W.;Hong, W.;Wu, Y.;Liu, Y.;Fan, X.;Wang, H.;Wang, M.;Yang, B.;Wang, T.;Li, H.;Liu, S.;Li, J.
关键词：assembly; reads; Nanopore sequencing; Illumina sequencing; bacterial identification
